Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 2/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 10/20 | 0.42 |
| ▸ | BACE1 | P56817 | 7/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7933959 | 0.82 | BACE1 (0.48) | BACE1BACE2 | |
| SCHEMBL7941942 | 0.76 | SORT1 (0.41) | PRKCIGRM4BACE1APP | |
| SCHEMBL12446239 | 0.75 | PRKCI (0.40) | PRKCIBACE1CYP3A4JAK2TYK2 | |
| SCHEMBL7944193 | 0.75 | GRM4 (0.50) | PRKCIGRM4BACE1CYP1A2CYP3A4 | |
| SCHEMBL19172612 | 0.72 | CFTR (0.43) | GRM4BACE1KCNH2APPBACE2 | |
| SCHEMBL12446209 | 0.72 | PRKCI (0.42) | PRKCIGRM4BACE1JAK2TYK2 | |
| SCHEMBL12445675 | 0.71 | BACE1 (0.49) | GRM4BACE1BACE2 | |
| SCHEMBL12446237 | 0.71 | BACE1 (0.47) | PRKCIGRM4BACE1BACE2 | |
| SCHEMBL16472030 | 0.71 | BACE1 (0.55) | BACE1BACE2 | |
| SCHEMBL12445674 | 0.71 | BACE1 (0.47) | PRKCIGRM4BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010047372-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | 塩野義製薬株式会社 (JP) | 2010-04-29 | — | — | WO | disclosed |