Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | BACE1 | P56817 | 7/20 | 0.46 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7942651 | 0.88 | BACE1 (0.47) | SMN1; SMN2NPC1RAB9ABACE1BACE2 | |
| SCHEMBL13195731 | 0.85 | SMN1; SMN2 (0.55) | SMN1; SMN2NPC1RAB9ABACE1BACE2 | |
| SCHEMBL7942303 | 0.82 | NPC1 (0.53) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL7942653 | 0.80 | BACE1 (0.46) | SMN1; SMN2NPC1RAB9ABACE1BACE2 | |
| SCHEMBL7942075 | 0.80 | ALDH1A1 (0.51) | SMN1; SMN2NPC1RAB9ABACE1POLB | |
| SCHEMBL12445781 | 0.79 | BACE1 (0.47) | SMN1; SMN2NPC1RAB9ABACE1BACE2 | |
| SCHEMBL7933959 | 0.79 | BACE1 (0.48) | BACE1BACE2 | |
| SCHEMBL12446185 | 0.78 | NPC1 (0.43) | SMN1; SMN2NPC1RAB9ABACE1BACE2 | |
| SCHEMBL12446234 | 0.78 | BACE1 (0.47) | SMN1; SMN2NPC1RAB9ABACE1BACE2 | |
| SCHEMBL15886228 | 0.78 | NPC1 (0.59) | SMN1; SMN2NPC1RAB9ABACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010047372-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | 塩野義製薬株式会社 (JP) | 2010-04-29 | — | — | WO | disclosed |