Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | NCOA2 | Q15596 | 2/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7929311 | 0.86 | ROCK1 (0.47) | MAPTTP53POLBSMN1; SMN2NPC1 | |
| SCHEMBL7932093 | 0.85 | ROCK1 (0.43) | MAPTTP53POLBKMT2AMEN1 | |
| SCHEMBL7930350 | 0.84 | POLB (0.51) | MAPTTP53POLBCYP11B2SMN1; SMN2 | |
| SCHEMBL7928073 | 0.80 | TRPV1 (0.42) | — | |
| SCHEMBL7930900 | 0.78 | MAPT (0.49) | MAPTTP53POLBSMN1; SMN2HSD17B10 | |
| SCHEMBL1938962 | 0.74 | MAPT (0.61) | MAPTTP53POLBCYP11B2NPC1 | |
| SCHEMBL30428550 | 0.74 | MAPT (0.61) | MAPTTP53POLBCYP11B2NPC1 | |
| SCHEMBL1938152 | 0.73 | MAPT (0.69) | MAPTTP53POLBCYP11B2SMN1; SMN2 | |
| SCHEMBL7930354 | 0.73 | SMN1; SMN2 (0.47) | MAPTPOLBSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7934017 | 0.72 | NPC1 (0.53) | MAPTPOLBSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059836-A1 | SUBSTITUTED AZA-BRIDGED BICYCLICS FOR CARDIOVASCULAR AND CNS DISEASE | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |