Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | FPR3 | P25089 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | AHCY | P23526 | 1/20 | 0.33 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PDE8B | O95263 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16474289 | 0.79 | PRMT5 (0.47) | KDM1AOPRD1ATMPRMT5 | |
| SCHEMBL19652083 | 0.73 | KDM1A (0.46) | KDM1AFPR3FPR2OPRD1SMN1; SMN2 | |
| SCHEMBL16474233 | 0.72 | KDM1A (0.44) | KDM1AFPR3FPR2OPRD1SMN1; SMN2 | |
| SCHEMBL19658763 | 0.71 | KDM1A (0.45) | KDM1AFPR3FPR2OPRD1AHCY | |
| SCHEMBL19652089 | 0.70 | OPRD1 (0.48) | KDM1AFPR3FPR2OPRD1SMN1; SMN2 | |
| SCHEMBL17753877 | 0.69 | KDM1A (0.48) | KDM1AFPR3FPR2OPRD1ATM | |
| SCHEMBL2452730 | 0.69 | OPRD1 (0.47) | KDM1AFPR3FPR2OPRD1SMN1; SMN2 | |
| SCHEMBL3078179 | 0.68 | KMT2A (0.45) | KDM1AFPR3FPR2OPRD1SMN1; SMN2 | |
| SCHEMBL13853714 | 0.68 | OPRD1 (0.51) | KDM1AFPR3FPR2OPRD1ATM | |
| SCHEMBL27353435 | 0.67 | KDM1A (0.48) | KDM1AFPR3FPR2OPRD1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010011912-A1 | TRPV4 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-01-28 | — | — | WO | disclosed |
| WO-2010011914-A1 | TRPV4 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-01-28 | — | — | WO | disclosed |