Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | FKBP1A | P62942 | 4/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | PREP | P48147 | 2/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20528094 | 0.88 | KDM1A (0.53) | PRMT5KDM1AFKBP1AABCB1OPRD1 | |
| SCHEMBL20522962 | 0.88 | KDM1A (0.53) | PRMT5KDM1AFKBP1AABCB1OPRD1 | |
| SCHEMBL30511036 | 0.88 | KDM1A (0.53) | PRMT5KDM1AFKBP1AABCB1OPRD1 | |
| SCHEMBL3086475 | 0.87 | CTSK (0.53) | CTSL | |
| SCHEMBL4738328 | 0.85 | OPRD1 (0.53) | PRMT5KDM1AFKBP1AABCB1OPRD1 | |
| SCHEMBL336766 | 0.85 | OPRD1 (0.53) | PRMT5KDM1AFKBP1AABCB1OPRD1 | |
| SCHEMBL337363 | 0.85 | OPRD1 (0.53) | PRMT5KDM1AFKBP1AABCB1OPRD1 | |
| SCHEMBL12496208 | 0.82 | FKBP1A (0.52) | PRMT5KDM1AFKBP1AOPRD1SYK | |
| SCHEMBL7934451 | 0.79 | KDM1A (0.39) | PRMT5KDM1AOPRD1ATM | |
| SCHEMBL30511007 | 0.79 | OPRD1 (0.49) | FKBP1AOPRD1SYKCTSLPREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2312947-B1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2014-01-01 | — | — | EP | disclosed |