Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.33 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.33 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.33 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7932213 | 0.87 | OPRM1 (0.45) | HTR2AOPRM1DRD4GRIN1GRIN2A | |
| Hydrochloric Acid SCHEMBL7925596 | 0.78 | HTR2A (0.35) | HTR2AOPRM1DRD4GRIN1GRIN2A | |
| Hydrochloric Acid SCHEMBL7925583 | 0.77 | MMP2 (0.36) | HTR2ASLC6A4HTR2CHTR2BMC4R | |
| SCHEMBL7245634 | 0.74 | HTR2A (0.44) | HTR2AOPRM1DRD4GRIN1GRIN2A | |
| Hydrochloric Acid SCHEMBL7925631 | 0.74 | CYP2D6 (0.41) | HTR2AOPRM1DRD4GRIN1GRIN2A | |
| Hydrochloric Acid SCHEMBL7934514 | 0.74 | OPRM1 (0.44) | OPRM1DRD4GRIN1GRIN2AGRIN2B | |
| Hydrochloric Acid SCHEMBL7934970 | 0.72 | SOS1 (0.37) | SOS1SOS2 | |
| Hydrochloric Acid SCHEMBL6830554 | 0.68 | HTR2A (0.42) | HTR2AOPRM1DRD4SIGMAR1SOS1 | |
| Hydrochloric Acid SCHEMBL7934502 | 0.68 | SOS1 (0.34) | SOS1SOS2 | |
| SCHEMBL11034435 | 0.68 | HTR2A (0.42) | HTR2AOPRM1DRD4SIGMAR1SOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6169152-B1 | COPOLYMER OF ETHYLENE AND A POLAR GROUP-CONTAINING CYCLIC OLEFIN COMPRISING ESTER- OR ANHYDRIDE MODIFIED NORBORNENE OR PERHYDRO-2,3-DIDEHYDRO-1,4:5,8-DIMETHANONAPHTHALENE MADE WITH CATALYST SUCH AS 1,5,9-TRIAZACYCLODODECANYLTITANIUM CHLORIDE | JSR CORPORATION (JP) | 2001-01-02 | — | — | US | disclosed |
| EP-0816387-A1 | Olefin-polymerizing catalyst | JAPAN SYNTHETIC RUBBER CO., LTD. (JP) | 1998-01-07 | — | — | EP | disclosed |