Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 7/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.49 |
| ▸ | PLAU | P00749 | 2/20 | 0.47 |
| ▸ | PLG | P00747 | 1/20 | 0.45 |
| ▸ | PLAT | P00750 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7940509 | 0.93 | MTNR1B (0.50) | MTNR1BMTNR1APLAUPLGPLAT | |
| SCHEMBL7935093 | 0.92 | MTNR1B (0.53) | MTNR1BMTNR1APLAUPLGPLAT | |
| SCHEMBL7928941 | 0.90 | RNF4 (0.51) | MTNR1BMTNR1APLAUPLGPLAT | |
| SCHEMBL7937751 | 0.90 | KMT2A (0.47) | MTNR1BMTNR1AKMT2AMEN1POLB | |
| SCHEMBL7935140 | 0.89 | MTNR1B (0.55) | MTNR1BMTNR1APLAUPLGPLAT | |
| SCHEMBL7937164 | 0.87 | MTNR1B (0.47) | MTNR1BPLAUKMT2AMEN1MAPT | |
| SCHEMBL7940421 | 0.84 | KDR (0.48) | MTNR1BMTNR1APLAUPLG | |
| SCHEMBL7938155 | 0.83 | MTNR1B (0.50) | MTNR1BMTNR1APLAUPLGPLAT | |
| SCHEMBL6050235 | 0.80 | MIF (0.46) | KMT2AMEN1CYP3A4CYP2C19 | |
| SCHEMBL8500385 | 0.80 | TDP1 (0.47) | MTNR1BMTNR1ADGAT2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835868-B1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | LILLY CO ELI (US) | 2001-08-29 | — | — | EP | disclosed |
| US-5929090-A | NOVEL COMPOUNDS FOR TREATING ESTROGEN DEPRIVATION CAUSED BY MENOPAUSE OR OVARIECTOMY; TREATING OSTEOPOROSIS, CARDIOVASCULAR DISEASES, AND ENDOMETRIOSIS | ELI LILLY AND COMPANY (US) | 1999-07-27 | — | — | US | disclosed |
| EP-0835868-A1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |