Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 9/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.50 |
| ▸ | RNF4 | P78317 | 1/20 | 0.49 |
| ▸ | PLG | P00747 | 3/20 | 0.48 |
| ▸ | PLAU | P00749 | 2/20 | 0.48 |
| ▸ | PLAT | P00750 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GMPS | P49915 | 1/20 | 0.43 |
| ▸ | KLK1 | P06870 | 2/20 | 0.43 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7928941 | 0.93 | RNF4 (0.51) | MTNR1BMTNR1ARNF4PLGPLAU | |
| SCHEMBL7928830 | 0.91 | PLAU (0.47) | MTNR1BMTNR1ARNF4PLGPLAU | |
| SCHEMBL7940509 | 0.90 | MTNR1B (0.50) | MTNR1BMTNR1APLGPLAUPLAT | |
| SCHEMBL7937755 | 0.86 | FGFR1 (0.44) | MTNR1BMTNR1ARNF4PLGPLAU | |
| SCHEMBL7935140 | 0.85 | MTNR1B (0.55) | MTNR1BMTNR1APLGPLAUPLAT | |
| SCHEMBL7935128 | 0.83 | MTNR1B (0.49) | MTNR1BMTNR1APLGPLAUPLAT | |
| SCHEMBL7935093 | 0.82 | MTNR1B (0.53) | MTNR1BMTNR1APLGPLAUPLAT | |
| SCHEMBL7940421 | 0.81 | KDR (0.48) | MTNR1BMTNR1APLGPLAUKLK1 | |
| SCHEMBL6050136 | 0.79 | ESR1 (0.50) | CYP3A4CYP2C19KMT2A | |
| SCHEMBL8502205 | 0.79 | MTNR1A (0.43) | MTNR1BMTNR1APLGPLAUPLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835868-B1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | LILLY CO ELI (US) | 2001-08-29 | — | — | EP | disclosed |
| US-5929090-A | NOVEL COMPOUNDS FOR TREATING ESTROGEN DEPRIVATION CAUSED BY MENOPAUSE OR OVARIECTOMY; TREATING OSTEOPOROSIS, CARDIOVASCULAR DISEASES, AND ENDOMETRIOSIS | ELI LILLY AND COMPANY (US) | 1999-07-27 | — | — | US | disclosed |
| EP-0835868-A1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |