Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7926722 | 0.95 | NISCH (0.34) | NISCHFYNCLK4DYRK1BCHRNB4 | |
| Hydrochloric Acid SCHEMBL7926820 | 0.87 | — | — | |
| Hydrochloric Acid SCHEMBL7938819 | 0.85 | NISCH (0.34) | NISCH | |
| Hydrochloric Acid SCHEMBL7933308 | 0.77 | SLC6A3 (0.32) | NISCHCHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL7737896 | 0.73 | — | — | |
| Hydrochloric Acid SCHEMBL7933311 | 0.69 | PTPN1 (0.32) | NISCHCHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL7935480 | 0.66 | NISCH (0.33) | NISCH | |
| Hydrochloric Acid SCHEMBL7926916 | 0.66 | FYN (0.33) | NISCHFYNCLK4DYRK1BCHRNB4 | |
| Hydrochloric Acid SCHEMBL7933161 | 0.65 | NISCH (0.35) | NISCH | |
| Hydrochloric Acid SCHEMBL7939082 | 0.63 | NISCH (0.33) | NISCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6184402-B1 | RESOLUTION OF A STEREOISOMERIC MIXTURE OF SPECIFIC METALLOCENE COMPLEXES BRIDGED WITH A TRANSITION METAL HAVING AN OXYGEN BOND ATTACHED, I.E., A MU-OXO COMPLEX; HYDROLYSIS IN THE PRESENCE OF A BASE; SEPARATION OF MESO FORM FROM MIXES | CHISSO CORPORATION (JP) | 2001-02-06 | — | — | US | disclosed |