Hydrochloric Acid

Hydrochloric Acid

SCHEMBL7933308

C1C[SiH2]C1.CC1=C([Zr+2]C2=C(C)C(c3ccc4ccccc4c3)=CC2C)C(C)C=C1c1ccc2ccccc2c1.[Cl-].[Cl-]

nearest known ligand 0.32

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A3 known ✓ Q01959 6/20 0.32
SLC6A2 known ✓ P23975 4/20 0.32
CHRNA1 known ✓ P02708 1/20 0.31
CHRNG known ✓ P07510 1/20 0.31
CHRNB1 known ✓ P11230 1/20 0.31
CHRND known ✓ Q07001 1/20 0.31
NISCH Q9Y2I1 1/20 0.31
CYP1A2 P05177 2/20 0.31
ALDH1A1 P00352 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2C9 P11712 1/20 0.31
HPGD P15428 1/20 0.31
TSHR P16473 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
HSD17B10 Q99714 1/20 0.31
PFKFB3 Q16875 1/20 0.31
CHRNB2 P17787 1/20 0.31
CHRNB4 P30926 1/20 0.31
SLC6A4 P31645 1/20 0.31
CHRNA3 P32297 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7936596 0.95 DKK1 (0.31) SLC6A3SLC6A2NISCHDKK1
Hydrochloric Acid SCHEMBL7936830 0.68 SLC6A3 (0.32) SLC6A3SLC6A2NISCHCYP1A2ALDH1A1
Hydrochloric Acid SCHEMBL7936368 0.66 CTRC (0.32) CYP1A2ALDH1A1CYP3A4CYP2C9HPGD
SCHEMBL30239998 0.58 ESR1 (0.71) CYP1A2ALDH1A1CYP3A4SMN1; SMN2HSD17B10
SCHEMBL30603836 0.58 ESR1 (0.71) CYP1A2ALDH1A1CYP3A4SMN1; SMN2HSD17B10
SCHEMBL15902840 0.58 ESR1 (0.71) CYP1A2ALDH1A1CYP3A4SMN1; SMN2HSD17B10
SCHEMBL239121 0.58 ESR1 (0.71) CYP1A2ALDH1A1CYP3A4SMN1; SMN2HSD17B10
SCHEMBL5013872 0.58 ESR1 (0.71) CYP1A2ALDH1A1CYP3A4SMN1; SMN2HSD17B10
SCHEMBL30239993 0.58 ESR1 (0.71) CYP1A2ALDH1A1CYP3A4SMN1; SMN2HSD17B10
SCHEMBL13950154 0.56 GSTP1 (0.47) NISCHCYP1A2ALDH1A1SMN1; SMN2HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6184402-B1 RESOLUTION OF A STEREOISOMERIC MIXTURE OF SPECIFIC METALLOCENE COMPLEXES BRIDGED WITH A TRANSITION METAL HAVING AN OXYGEN BOND ATTACHED, I.E., A MU-OXO COMPLEX; HYDROLYSIS IN THE PRESENCE OF A BASE; SEPARATION OF MESO FORM FROM MIXES CHISSO CORPORATION (JP) 2001-02-06 US disclosed