Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | BCHE | P06276 | 8/20 | 0.53 |
| ▸ | ACHE | P22303 | 7/20 | 0.53 |
| ▸ | APP | P05067 | 2/20 | 0.53 |
| ▸ | BACE1 | P56817 | 2/20 | 0.53 |
| ▸ | GABRP | O00591 | 1/20 | 0.53 |
| ▸ | GABRD | O14764 | 1/20 | 0.53 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.53 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.53 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.53 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.53 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.53 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.53 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.53 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.53 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.53 |
| ▸ | GABRE | P78334 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8020561 | 0.85 | LMNA (0.61) | TP53SMN1; SMN2HTTBCHEACHE | |
| SCHEMBL7935359 | 0.84 | BCHE (0.61) | HTTBCHEACHEAPPBACE1 | |
| SCHEMBL8020560 | 0.83 | BCHE (0.60) | HTTBCHEACHEAPPBACE1 | |
| SCHEMBL7944948 | 0.82 | KMT2A (0.64) | HTTBCHEACHEBACE1 | |
| SCHEMBL8004829 | 0.80 | APP (0.58) | BCHEACHEAPPBACE1GABRP | |
| SCHEMBL8013008 | 0.79 | BCHE (0.53) | BCHEACHEAPPBACE1GABRP | |
| SCHEMBL8017099 | 0.78 | MEN1 (0.67) | MAPTHTTBCHEACHEAPP | |
| SCHEMBL7935378 | 0.78 | ACHE (0.60) | BCHEACHEAPPBACE1GABRP | |
| SCHEMBL7944432 | 0.77 | BCHE (0.65) | HTTBCHEACHEAPPBACE1 | |
| SCHEMBL8018033 | 0.76 | BCHE (0.58) | BCHEACHEAPPBACE1GABRP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6075144-A | ABILITY TO INHIBIT ACETYLCHOLINESTERASE; TREATS ALZHEIMER,S DISEASE | HOECHST MARION ROUSSEL, INC. (US) | 2000-06-13 | — | — | US | claimed |
| US-6248750-B1 | CHOLINERGIC FUNCTION AGONISTS FOR MEMORY ENHANCEMENT | HOECHST ROUSSEL PHARMACEUTICALS | 2001-06-19 | — | — | US | disclosed |
| US-6075144-A | ABILITY TO INHIBIT ACETYLCHOLINESTERASE; TREATS ALZHEIMER,S DISEASE | HOECHST MARION ROUSSEL, INC. (US) | 2000-06-13 | — | — | US | disclosed |