Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | BCHE | P06276 | 9/20 | 0.59 |
| ▸ | ACHE | P22303 | 9/20 | 0.59 |
| ▸ | BACE1 | P56817 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7935359 | 0.97 | BCHE (0.61) | KMT2AKDM4EMEN1HTTBCHE | |
| SCHEMBL8020560 | 0.96 | BCHE (0.60) | KMT2AKDM4EMEN1HTTBCHE | |
| SCHEMBL8004829 | 0.90 | APP (0.58) | BCHEACHEBACE1 | |
| SCHEMBL8020561 | 0.90 | LMNA (0.61) | KMT2AKDM4EMEN1HTTBCHE | |
| SCHEMBL7944432 | 0.85 | BCHE (0.65) | KMT2AKDM4EMEN1HTTBCHE | |
| SCHEMBL8013008 | 0.82 | BCHE (0.53) | BCHEACHEBACE1 | |
| SCHEMBL7935366 | 0.82 | TP53 (0.57) | HTTBCHEACHEBACE1 | |
| SCHEMBL8017099 | 0.81 | MEN1 (0.67) | KMT2AKDM4EMEN1HTTBCHE | |
| SCHEMBL8004824 | 0.81 | KMT2A (0.64) | KMT2AKDM4EMEN1HTTBCHE | |
| SCHEMBL7935378 | 0.81 | ACHE (0.60) | BCHEACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6075144-A | ABILITY TO INHIBIT ACETYLCHOLINESTERASE; TREATS ALZHEIMER,S DISEASE | HOECHST MARION ROUSSEL, INC. (US) | 2000-06-13 | — | — | US | claimed |
| US-6248750-B1 | CHOLINERGIC FUNCTION AGONISTS FOR MEMORY ENHANCEMENT | HOECHST ROUSSEL PHARMACEUTICALS | 2001-06-19 | — | — | US | disclosed |
| US-6075144-A | ABILITY TO INHIBIT ACETYLCHOLINESTERASE; TREATS ALZHEIMER,S DISEASE | HOECHST MARION ROUSSEL, INC. (US) | 2000-06-13 | — | — | US | disclosed |
| EP-0288852-B1 | 9-HYDROXYAMINO TETRAHYDRO-ACRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-07-28 | — | — | EP | disclosed |
| EP-0288852-A1 | 9-Hydroxyamino tetrahydro-acridines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-11-02 | — | — | EP | disclosed |