Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27546018 | 0.69 | ALDH1A1 (0.39) | MEN1ALDH1A1MAPTKMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL27546051 | 0.69 | ALDH1A1 (0.39) | MEN1ALDH1A1MAPTKMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL27546019 | 0.66 | ALDH1A1 (0.39) | MEN1ALDH1A1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL18661495 | 0.55 | ACHE (0.73) | ALDH1A1 | |
| SCHEMBL3287696 | 0.55 | ACHE (0.73) | ALDH1A1 | |
| SCHEMBL197731 | 0.55 | ACHE (0.73) | ALDH1A1 | |
| SCHEMBL21698476 | 0.53 | ACHE (0.39) | MEN1ALDH1A1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL4624878 | 0.53 | CFTR (0.37) | ALDH1A1KMT2A | |
| Water SCHEMBL3680095 | 0.53 | ACHE (0.67) | ALDH1A1 | |
| SCHEMBL31591282 | 0.53 | ACHE (0.67) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6184402-B1 | RESOLUTION OF A STEREOISOMERIC MIXTURE OF SPECIFIC METALLOCENE COMPLEXES BRIDGED WITH A TRANSITION METAL HAVING AN OXYGEN BOND ATTACHED, I.E., A MU-OXO COMPLEX; HYDROLYSIS IN THE PRESENCE OF A BASE; SEPARATION OF MESO FORM FROM MIXES | CHISSO CORPORATION (JP) | 2001-02-06 | — | — | US | disclosed |