Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | PFKFB3 | Q16875 | 6/20 | 0.53 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.50 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.45 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | CCNH | P51946 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL794311 | 0.90 | PFKFB3 (0.65) | MAPTLMNATP53THRBPFKFB3 | |
| SCHEMBL792880 | 0.88 | PFKFB3 (0.54) | MAPTLMNATP53THRBPFKFB3 | |
| SCHEMBL793762 | 0.87 | PFKFB3 (0.47) | MAPTLMNATP53THRBPFKFB3 | |
| SCHEMBL793853 | 0.85 | PFKFB3 (0.49) | MAPTLMNATP53THRBPFKFB3 | |
| SCHEMBL793409 | 0.84 | PFKFB3 (0.55) | LMNATHRBPFKFB3MEN1KMT2A | |
| SCHEMBL793555 | 0.83 | PFKFB3 (0.66) | MAPTLMNATP53THRBPFKFB3 | |
| SCHEMBL794260 | 0.83 | PFKFB3 (0.53) | MAPTLMNAPFKFB3MEN1KMT2A | |
| SCHEMBL793284 | 0.83 | ALDH1A1 (0.52) | MAPTPFKFB3MEN1KMT2ALNPEP | |
| SCHEMBL794362 | 0.83 | PFKFB3 (0.68) | MAPTLMNATP53THRBPFKFB3 | |
| SCHEMBL15063707 | 0.83 | LMNA (0.50) | MAPTLMNATP53THRBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616450-A2 | SULFONAMIDE COMPOUNDS | Kancera AB (SE) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012035171-A2 | NEW COMPOUNDS | KANCERA AB (SE) | 2012-03-22 | — | — | WO | disclosed |