Niravoline

Niravoline

SCHEMBL7935616

CN(C(=O)Cc1cccc([N+](=O)[O-])c1)C1c2ccccc2CC1N1CCCC1

nearest known ligand 0.67

Full drug profile on Sugi Atlas →

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 13/20 0.67
OPRK1 P41145 4/20 0.56
OPRM1 P35372 3/20 0.56
OPRD1 P41143 3/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Niravoline SCHEMBL29388767 1.00 SIGMAR1 (0.67) SIGMAR1OPRK1OPRM1OPRD1
Niravoline SCHEMBL637489 1.00 SIGMAR1 (0.67) SIGMAR1OPRK1OPRM1OPRD1
Niravoline SCHEMBL9250990 1.00 SIGMAR1 (0.67) SIGMAR1OPRK1OPRM1OPRD1
Niravoline SCHEMBL7942442 0.99 SIGMAR1 (0.66) SIGMAR1OPRK1OPRM1OPRD1
Niravoline SCHEMBL7747722 0.99 SIGMAR1 (0.66) SIGMAR1OPRK1OPRM1OPRD1
SCHEMBL9260449 0.90 SIGMAR1 (0.64) SIGMAR1OPRK1OPRM1OPRD1
SCHEMBL9510530 0.90 SIGMAR1 (0.64) SIGMAR1OPRK1OPRM1OPRD1
SCHEMBL7966344 0.90 SIGMAR1 (0.64) SIGMAR1OPRK1OPRM1OPRD1
SCHEMBL9644180 0.90 SIGMAR1 (0.64) SIGMAR1OPRK1OPRM1OPRD1
SCHEMBL9512728 0.88 SIGMAR1 (0.64) SIGMAR1OPRK1OPRM1OPRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6174878-B1 OR INTRANASAL COMPOSITION E.G., ASIMADOLINE (EMD-61753), ENADOLINE, BENZENEACETAMIDE, AS AN ANALGESIC FOR EAR INFECTION, SWIMMER'S EAR, ETC.; ACTIVATION OF SPECIFIC RECEPTORS SO NO SIDE EFFECTS ALCON LABORATORIES, INC. 2001-01-16 US claimed
US-5348971-A Indanes useful as analgesics ROUSSEL UCLAF (FR) 1994-09-20 US claimed
EP-0374054-B1 INDANE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND INTERMEDIATES OBTAINED, THEIR USE AS MEDICINES, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM ROUSSEL-UCLAF (FR) 1993-10-06 EP claimed
US-6271395-B1 E.G.,(.+-.)-N-(2,3-DIHYDRO-2-(1-PYRROLIDINYL)-1H-INDEN-1-Y1) -2 ,4-DINITRO-N-METHYL-BENZENE-ACETAMIDE; STRONG AFFINITY FOR OPTICAL RECEPTORS, CENTRAL ANALGESIC, DIURETIC, ANTIARRYTHMIC, HYPOTENSIVE AND ANTIISCHEMIC ACTIVITY. HOECHST MARION ROUSSOL (FR) 2001-08-07 US disclosed
US-6268359-B1 Preventives or remedies for vision disorders SENJU PHARMACEUTICAL CO., LTD. (JP) 2001-07-31 US disclosed
US-6174878-B1 OR INTRANASAL COMPOSITION E.G., ASIMADOLINE (EMD-61753), ENADOLINE, BENZENEACETAMIDE, AS AN ANALGESIC FOR EAR INFECTION, SWIMMER'S EAR, ETC.; ACTIVATION OF SPECIFIC RECEPTORS SO NO SIDE EFFECTS ALCON LABORATORIES, INC. 2001-01-16 US disclosed
EP-1050308-A1 PREVENTIVES OR REMEDIES FOR VISION DISORDERS Senju Pharmaceutical Co., Ltd. (JP) 2000-11-08 EP disclosed
US-5436244-A Antiarrhythmia agents ROUSSEL UCLAF (FR) 1995-07-25 US disclosed
US-5348971-A Indanes useful as analgesics ROUSSEL UCLAF (FR) 1994-09-20 US disclosed
EP-0374054-B1 INDANE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND INTERMEDIATES OBTAINED, THEIR USE AS MEDICINES, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM ROUSSEL-UCLAF (FR) 1993-10-06 EP disclosed