Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 13/20 | 0.67 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.56 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Niravoline SCHEMBL7935616 | 1.00 | SIGMAR1 (0.67) | SIGMAR1OPRK1OPRM1OPRD1 | |
| Niravoline SCHEMBL29388767 | 1.00 | SIGMAR1 (0.67) | SIGMAR1OPRK1OPRM1OPRD1 | |
| Niravoline SCHEMBL637489 | 1.00 | SIGMAR1 (0.67) | SIGMAR1OPRK1OPRM1OPRD1 | |
| Niravoline SCHEMBL7942442 | 0.99 | SIGMAR1 (0.66) | SIGMAR1OPRK1OPRM1OPRD1 | |
| Niravoline SCHEMBL7747722 | 0.99 | SIGMAR1 (0.66) | SIGMAR1OPRK1OPRM1OPRD1 | |
| SCHEMBL9260449 | 0.90 | SIGMAR1 (0.64) | SIGMAR1OPRK1OPRM1OPRD1 | |
| SCHEMBL9510530 | 0.90 | SIGMAR1 (0.64) | SIGMAR1OPRK1OPRM1OPRD1 | |
| SCHEMBL7966344 | 0.90 | SIGMAR1 (0.64) | SIGMAR1OPRK1OPRM1OPRD1 | |
| SCHEMBL9644180 | 0.90 | SIGMAR1 (0.64) | SIGMAR1OPRK1OPRM1OPRD1 | |
| SCHEMBL9512728 | 0.88 | SIGMAR1 (0.64) | SIGMAR1OPRK1OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0258096-B1 | INDANE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THE INTERMEDIATES OBTAINED | ROUSSEL-UCLAF (FR) | 1992-09-09 | — | — | EP | claimed |
| US-5436244-A | Antiarrhythmia agents | ROUSSEL UCLAF (FR) | 1995-07-25 | — | — | US | disclosed |
| US-5348971-A | Indanes useful as analgesics | ROUSSEL UCLAF (FR) | 1994-09-20 | — | — | US | disclosed |
| EP-0374054-B1 | INDANE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND INTERMEDIATES OBTAINED, THEIR USE AS MEDICINES, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1993-10-06 | — | — | EP | disclosed |
| US-5043347-A | Indanes and analgesic compositions and methods thereof | ROUSSEL UCLAF (FR) | 1991-08-27 | — | — | US | disclosed |