Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.64 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.56 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.56 |
| ▸ | CCR5 | P51681 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7966344 | 1.00 | SIGMAR1 (0.64) | SIGMAR1OPRK1OPRM1OPRD1CCR5 | |
| SCHEMBL9493831 | 0.90 | SIGMAR1 (0.69) | SIGMAR1OPRK1OPRM1OPRD1CCR5 | |
| SCHEMBL9496323 | 0.90 | SIGMAR1 (0.69) | SIGMAR1OPRK1OPRM1OPRD1CCR5 | |
| Niravoline SCHEMBL7935616 | 0.90 | SIGMAR1 (0.67) | SIGMAR1OPRK1OPRM1OPRD1 | |
| Niravoline SCHEMBL637489 | 0.90 | SIGMAR1 (0.67) | SIGMAR1OPRK1OPRM1OPRD1 | |
| Niravoline SCHEMBL29388767 | 0.90 | SIGMAR1 (0.67) | SIGMAR1OPRK1OPRM1OPRD1 | |
| Niravoline SCHEMBL9250990 | 0.90 | SIGMAR1 (0.67) | SIGMAR1OPRK1OPRM1OPRD1 | |
| Niravoline SCHEMBL7747722 | 0.89 | SIGMAR1 (0.66) | SIGMAR1OPRK1OPRM1OPRD1 | |
| Niravoline SCHEMBL7942442 | 0.89 | SIGMAR1 (0.66) | SIGMAR1OPRK1OPRM1OPRD1 | |
| SCHEMBL9772344 | 0.87 | SIGMAR1 (0.61) | SIGMAR1OPRK1OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0258096-B1 | INDANE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THE INTERMEDIATES OBTAINED | ROUSSEL-UCLAF (FR) | 1992-09-09 | — | — | EP | claimed |
| US-5043347-A | Indanes and analgesic compositions and methods thereof | ROUSSEL UCLAF (FR) | 1991-08-27 | — | — | US | disclosed |