Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | CTSS | P25774 | 3/20 | 0.43 |
| ▸ | CTSK | P43235 | 3/20 | 0.43 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.41 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methane SCHEMBL7718636 | 0.89 | HDAC4 (0.46) | MAPTCTSSCTSKCTSBSMN1; SMN2 | |
| SCHEMBL7721375 | 0.86 | KDM4E (0.43) | ALDH1A1KDM4ELMNAHPGDTHRB | |
| SCHEMBL7936792 | 0.84 | KLK5 (0.50) | ALDH1A1KDM4ELMNAHPGDTHRB | |
| SCHEMBL7709234 | 0.81 | TRPV1 (0.44) | ALDH1A1KDM4EHPGDNPC1RAB9A | |
| SCHEMBL7719351 | 0.77 | HDAC4 (0.46) | KDM4EMAPTCTSSCTSKCTSB | |
| SCHEMBL7719355 | 0.77 | HDAC4 (0.46) | KDM4EMAPTCTSSCTSKCTSB | |
| SCHEMBL11036298 | 0.76 | HDAC4 (0.53) | ALDH1A1KDM4ELMNAHPGDTHRB | |
| Methane SCHEMBL7721379 | 0.75 | AAK1 (0.41) | ALDH1A1KDM4EMAPTCTSSCTSK | |
| SCHEMBL6556874 | 0.74 | CTSS (0.54) | ALDH1A1KDM4ELMNAHPGDMAPT | |
| SCHEMBL7627072 | 0.74 | CTSS (0.42) | ALDH1A1KDM4EHPGDMAPTCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441017-B1 | Inhibitors of prenyl-protein transferase | MERCK & CO., INC. | 2002-08-27 | — | — | US | disclosed |