Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.31 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 2/20 | 0.31 |
| ▸ | MMP9 | P14780 | 2/20 | 0.31 |
| ▸ | ANPEP | P15144 | 2/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | LAP3 | P28838 | 1/20 | 0.31 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.31 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.31 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6940018 | 0.89 | MMP2 (0.33) | P2RX3CTSKMMP2MMP9ANPEP | |
| SCHEMBL6943194 | 0.88 | P2RX3 (0.30) | P2RX3 | |
| SCHEMBL6945957 | 0.86 | ADAM17 (0.34) | P2RX3MMP2MMP9ANPEPLTA4H | |
| SCHEMBL6943373 | 0.85 | ADAM17 (0.33) | P2RX3CTSKMMP2MMP9ANPEP | |
| SCHEMBL6937784 | 0.85 | ADAM17 (0.33) | P2RX3CTSKMMP2MMP9ANPEP | |
| SCHEMBL6943556 | 0.84 | ADAM17 (0.33) | P2RX3MMP2MMP9ANPEPLTA4H | |
| SCHEMBL8111706 | 0.84 | ADAM17 (0.33) | P2RX3MMP2MMP9ANPEPLTA4H | |
| SCHEMBL6942209 | 0.84 | ADAM17 (0.33) | P2RX3MMP2MMP9ANPEPLTA4H | |
| SCHEMBL6940960 | 0.83 | TP53 (0.31) | TP53KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL6945554 | 0.83 | ADAM17 (0.33) | P2RX3MMP2MMP9ANPEPLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |