Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.52 |
| ▸ | NCF1 | P14598 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29632675 | 0.89 | NCF1 (0.45) | HRH3NCF1SMN1; SMN2MAPTCXCR4 | |
| SCHEMBL798244 | 0.89 | HRH3 (0.49) | HRH3NCF1SMN1; SMN2MAPTCXCR4 | |
| SCHEMBL31703161 | 0.85 | NCF1 (0.42) | HRH3NCF1SMN1; SMN2MAPTCXCR4 | |
| SCHEMBL29632667 | 0.81 | HRH4 (0.47) | HRH3SMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL29632617 | 0.80 | CSF1R (0.39) | HRH3NCF1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL29632665 | 0.80 | CNR2 (0.40) | HRH3NCF1SMN1; SMN2MAPTJAK2 | |
| SCHEMBL29632612 | 0.80 | HRH3 (0.48) | HRH3NCF1MAPTJAK2 | |
| SCHEMBL30605619 | 0.80 | NCF1 (0.54) | HRH3NCF1SMN1; SMN2CXCR4JAK2 | |
| SCHEMBL2236500 | 0.80 | NCF1 (0.54) | HRH3NCF1SMN1; SMN2CXCR4JAK2 | |
| SCHEMBL29632669 | 0.79 | CA2 (0.42) | NCF1SMN1; SMN2CNR2NPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012035055-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-22 | — | — | WO | disclosed |
| WO-2012035055-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-22 | — | — | WO | disclosed |