Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.30 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.37 |
| ▸ | HPGD | P15428 | 5/20 | 0.37 |
| ▸ | TSHR | P16473 | 5/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7651339 | 0.97 | HSD17B10 (0.39) | HSD17B10HPGDTSHRCYP3A4L3MBTL1 | |
| SCHEMBL5477612 | 0.84 | KDM1A (0.44) | HSD17B10HPGDTSHRCYP3A4ALDH1A1 | |
| SCHEMBL3214317 | 0.77 | MYB (0.40) | HSD17B10HPGDCYP3A4MAPK1ALDH1A1 | |
| SCHEMBL3209431 | 0.75 | EPHX1 (0.35) | CYP3A4L3MBTL1RAB9AALDH1A1CYP1A2 | |
| SCHEMBL3201778 | 0.75 | MEN1 (0.33) | HSD17B10ATMALDH1A1KDM1ACYP2A6 | |
| SCHEMBL3207496 | 0.75 | MAPT (0.36) | HSD17B10HPGDTSHRL3MBTL1RAB9A | |
| SCHEMBL3208869 | 0.75 | KMT2A (0.49) | HPGDL3MBTL1ALDH1A1THRBMEN1 | |
| SCHEMBL3208877 | 0.75 | KMT2A (0.49) | HPGDL3MBTL1ALDH1A1THRBMEN1 | |
| SCHEMBL3207501 | 0.75 | MAPT (0.36) | HSD17B10HPGDTSHRL3MBTL1RAB9A | |
| SCHEMBL7034020 | 0.74 | ALDH1A1 (0.37) | HSD17B10HPGDHIF1AALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1110977-A1 | Transition metal-catalyzed polymerisation of olefinic monomers in aqueous polymeric medium | BASF AKTIENGESELLSCHAFT (DE) | 2001-06-27 | — | — | EP | disclosed |