SCHEMBL7937584

SCHEMBL7937584

C[Si](C)(C)C[Si](C)(C1=CC=CC1)C1=Cc2ccccc2C1

nearest known ligand 0.31

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.31
CYP11B1 P15538 1/20 0.30
CYP11B2 P19099 1/20 0.30
PTGS2 P35354 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7943196 0.81 ACHE (0.34) ACHECYP11B1CYP11B2PTGS2
SCHEMBL2743954 0.69 CYP11B2 (0.41) ACHECYP11B1CYP11B2PTGS2
SCHEMBL15121440 0.69 CYP11B2 (0.41) ACHECYP11B1CYP11B2PTGS2
SCHEMBL1452101 0.69 ACHE (0.41) ACHECYP11B1CYP11B2PTGS2
Hydrochloric Acid SCHEMBL7943910 0.69 CYP11B2 (0.33) CYP11B1CYP11B2PTGS2
Hydrochloric Acid SCHEMBL7946663 0.69 CYP11B2 (0.33) CYP11B1CYP11B2PTGS2
SCHEMBL8854215 0.68 ACHE (0.40) ACHECYP11B1CYP11B2PTGS2
Hydrochloric Acid SCHEMBL8319503 0.67 CYP11B2 (0.39) ACHECYP11B1CYP11B2PTGS2
Hydrochloric Acid SCHEMBL6761120 0.67 ACHE (0.39) ACHECYP11B1CYP11B2PTGS2
SCHEMBL2235110 0.67 CYP11B2 (0.39) ACHECYP11B1CYP11B2PTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6248912-B1 OF TRANSITION METALS HAVING A TETRAHYDROINDENYL LIGAND BONDED IN THE 2-POSITION BAYER AKTIENGESELLSCHAFT (DE) 2001-06-19 US disclosed