SCHEMBL2235110

SCHEMBL2235110

C[Si](C)(Cl)C1=Cc2ccccc2C1

nearest known ligand 0.39

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYP11B2 P19099 3/20 0.39
PTGS2 P35354 2/20 0.39
CYP11B1 P15538 2/20 0.39
TRPA1 O75762 1/20 0.37
MAOA P21397 2/20 0.37
MAOB P27338 2/20 0.37
ACHE P22303 1/20 0.36
DRD2 P14416 2/20 0.34
DRD4 P21917 2/20 0.34
MTNR1A P48039 1/20 0.33
MTNR1B P49286 1/20 0.33
GPR84 Q9NQS5 1/20 0.32
CYP19A1 P11511 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15121440 0.83 CYP11B2 (0.41) CYP11B2PTGS2CYP11B1TRPA1MAOA
SCHEMBL2743954 0.83 CYP11B2 (0.41) CYP11B2PTGS2CYP11B1TRPA1MAOA
SCHEMBL1452101 0.83 ACHE (0.41) CYP11B2PTGS2CYP11B1TRPA1MAOA
SCHEMBL8854215 0.82 ACHE (0.40) CYP11B2PTGS2CYP11B1TRPA1MAOA
Hydrochloric Acid SCHEMBL8319503 0.80 CYP11B2 (0.39) CYP11B2PTGS2CYP11B1TRPA1MAOA
Hydrochloric Acid SCHEMBL6761124 0.80 CYP11B2 (0.42) CYP11B2PTGS2CYP11B1TRPA1MAOA
Hydrochloric Acid SCHEMBL6761120 0.80 ACHE (0.39) CYP11B2PTGS2CYP11B1TRPA1MAOA
Hydrochloric Acid SCHEMBL8319505 0.80 CYP11B2 (0.42) CYP11B2PTGS2CYP11B1TRPA1MAOA
SCHEMBL10277639 0.74 PTGS2 (0.45) CYP11B2PTGS2CYP11B1TRPA1MAOA
SCHEMBL5179240 0.73 CYP11B2 (0.34) CYP11B2PTGS2CYP11B1TRPA1MAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118221849-A Application of metallocene catalyst composition as catalyst in preparation of poly alpha olefin wax 亚培烯科技(上海)有限公司 2024-06-21 CN disclosed
US-20160354483-A1 COMPOUNDS, CONJUGATES AND COMPOSITIONS OF EPIPOLYTHIODIKETOPIPERAZINES AND POLYTHIODIKETOPIPERAZINES MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2016-12-08 US disclosed
US-9353150-B2 Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2016-05-31 US disclosed
US-20140187500-A1 COMPOUNDS, CONJUGATES AND COMPOSITIONS OF EPIPOLYTHIODIKETOPIPERAZINES AND POLYTHIODIKETOPIPERAZINES THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2014-07-03 US disclosed
US-8545980-B2 Polypropylene resin, fiber, and nonwoven fabric IDEMITSU KOSAN CO., LTD. (JP) 2013-10-01 US disclosed
EP-1260525-B1 1-BUTENE POLYMER AND MOLDED PRODUCT CONSISTING OF THE POLYMER IDEMITSU KOSAN CO (JP) 2012-12-12 EP disclosed
EP-2264077-B1 1-Butene based polymer and the product formed therefrom IDEMITSU KOSAN CO (JP) 2012-06-13 EP disclosed
US-7981959-B2 Resin composition, process for producing the same and molding of the resin composition IDEMITSU KOSAN CO., LTD. (JP) 2011-07-19 US disclosed
EP-2264077-A1 1-Butene based polymer and the product formed therefrom Idemitsu Kosan Co., Ltd. (JP) 2010-12-22 EP disclosed
US-7842748-B2 Master batch composition, polyolefin resin composition comprising the same, and molded product thereof IDEMITSU KOSAN CO., LTD. (JP) 2010-11-30 US disclosed
US-20030069320-A1 1-Butene polymer and molded product consisting of the polymer IDEMITSU KOSAN CO. LTD. (JP) 2003-04-10 US disclosed
EP-1260525-A1 1-BUTENE POLYMER AND MOLDED PRODUCT CONSISTING OF THE POLYMER IDEMITSU PETROCHEMICAL CO., LTD. (JP) 2002-11-27 EP disclosed
US-6329478-B1 SOLUBILITY IN SATURATED HYDROCARBON SOLVENTS SUMITMO CHEMICAL COMPANY, LIMITED 2001-12-11 US disclosed
EP-1153947-A1 OLEFIN COPOLYMER, FILM, AND SHEET IDEMITSU PETROCHEMICAL CO., LTD. (JP) 2001-11-14 EP disclosed
EP-1153944-A1 PROPYLENE POLYMER, MOLDED OBJECT THEREOF, AND PROCESS FOR PRODUCING PROPYLENE POLYMER IDEMITSU PETROCHEMICAL CO., LTD. (JP) 2001-11-14 EP disclosed
US-6248912-B1 OF TRANSITION METALS HAVING A TETRAHYDROINDENYL LIGAND BONDED IN THE 2-POSITION BAYER AKTIENGESELLSCHAFT (DE) 2001-06-19 US disclosed
EP-1095951-A1 PROPYLENE POLYMER AND COMPOSITION CONTAINING THE SAME, MOLDED OBJECT AND LAMINATE COMPRISING THESE, AND PROCESSES FOR PRODUCING PROPYLENE POLYMER AND COMPOSITION CONTAINING THE SAME IDEMITSU PETROCHEMICAL CO., LTD. (JP) 2001-05-02 EP disclosed
EP-0940408-A1 Metalorganic compounds Bayer Aktiengesellschaft (DE) 1999-09-08 EP disclosed
EP-0940412-A1 Atactic propylene (co)polymers Bayer Aktiengesellschaft (DE) 1999-09-08 EP disclosed
EP-0842939-A1 TRANSITION METAL COMPLEX, PROCESS FOR THE PREPARATION THEREOF, POLYMERIZATION CATALYST FOR OLEFINS CONTAINING THE COMPLEX, AND PROCESS FOR PRODUCING OLEFIN POLYMERS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-05-20 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140187500-A1 COMPOUNDS, CONJUGATES AND COMPOSITIONS OF EPIPOLYTHIODIKETOPIPERAZINES AND POLYTHIODIKETOPIPERAZINES DNPEP, NPEPPS, PIN1 CYP11B2 458/4885PTGS2 1919/4885CYP11B1 750/4885
US-20160354483-A1 COMPOUNDS, CONJUGATES AND COMPOSITIONS OF EPIPOLYTHIODIKETOPIPERAZINES AND POLYTHIODIKETOPIPERAZINES DNPEP, NPEPPS, PIN1 CYP11B2 458/4885PTGS2 1919/4885CYP11B1 750/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.