SCHEMBL7937757

SCHEMBL7937757

COc1ccc(C[C@H](C)OS(=O)(=O)c2ccc(C)cc2)cc1OC

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.51
SMN1; SMN2 Q16637 3/20 0.51
LDHA P00338 1/20 0.50
ALOX15 P16050 1/20 0.44
ALOX12 P18054 1/20 0.44
ALDH1A1 P00352 1/20 0.44
GAA P10253 1/20 0.44
CA1 P00915 2/20 0.43
CA2 P00918 2/20 0.43
CA9 Q16790 2/20 0.43
CA12 O43570 1/20 0.43
CA4 P22748 1/20 0.43
PAX8 Q06710 1/20 0.43
CYP24A1 Q07973 1/20 0.43
EPHX2 P34913 1/20 0.43
POLB P06746 2/20 0.43
PTGER1 P34995 1/20 0.43
TSHR P16473 1/20 0.43
MAPK1 P28482 1/20 0.43
GFER P55789 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7937189 1.00 LMNA (0.51) LMNASMN1; SMN2LDHAALOX15ALOX12
SCHEMBL7937120 1.00 LMNA (0.51) LMNASMN1; SMN2LDHAALOX15ALOX12
SCHEMBL11370375 0.81 CYP24A1 (0.50) LMNASMN1; SMN2ALDH1A1CYP24A1MAPK1
SCHEMBL11375399 0.81 TAAR1 (0.51) LMNAALDH1A1CYP24A1POLBMAPT
SCHEMBL7937790 0.80 LDHA (0.58) LMNASMN1; SMN2LDHAALOX15ALOX12
SCHEMBL7940348 0.80 LDHA (0.58) LMNASMN1; SMN2LDHAALOX15ALOX12
SCHEMBL7937788 0.80 LDHA (0.58) LMNASMN1; SMN2LDHAALOX15ALOX12
SCHEMBL7938217 0.80 ALOX15 (0.47) LMNAALOX15ALOX12ALDH1A1GAA
SCHEMBL7938214 0.80 ALOX15 (0.47) LMNAALOX15ALOX12ALDH1A1GAA
SCHEMBL7938299 0.80 ALOX15 (0.47) LMNAALOX15ALOX12ALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6248573-B1 SULFONYLATING OR HALOGENATING A (S)-1-PHENYL-2-PROPANOL DERIVATIVE TO PRODUCE (S)-1-PHENYL-2-SUBSTITUTED PROPANE DERIVATIVE; CHEMICAL INTERMEDIATE FOR SYNTHESIS OF ANTIOBESITY DRUG DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 2001-06-19 US disclosed
EP-0627397-B1 Optically active 1-phenyl-2-substituted propane derivatives and methods of producing the same DAICEL CHEM (JP) 1997-01-02 EP disclosed
US-5508461-A ANTIOBESITY AGENTS DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1996-04-16 US disclosed
EP-0627397-A1 Optically active 1-phenyl-2-substituted propane derivatives and methods of producing the same DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1994-12-07 EP disclosed