Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7605151 | 0.93 | KDM4E (0.30) | KDM4EALDH1A1LMNAMAPK1 | |
| SCHEMBL7604535 | 0.90 | ALDH1A1 (0.32) | KDM4EALDH1A1LMNAMAPK1 | |
| SCHEMBL7606630 | 0.89 | KDM4E (0.31) | KDM4EALDH1A1LMNAMAPK1 | |
| Hydrochloric Acid SCHEMBL7195300 | 0.82 | MAPT (0.31) | — | |
| Hydrochloric Acid SCHEMBL7939984 | 0.81 | — | — | |
| Hydrochloric Acid SCHEMBL7931298 | 0.81 | — | — | |
| SCHEMBL5174322 | 0.79 | MAPT (0.33) | — | |
| Hydrochloric Acid SCHEMBL7939283 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL7603013 | 0.76 | MEN1 (0.31) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7940430 | 0.76 | MEN1 (0.31) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123938-A2 | Organometallic fluorenyl compounds, preparation, and use | PHILLIPS PETROLEUM COMPANY (US) | 2001-08-16 | — | — | EP | disclosed |