Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 8/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PI4KA | P42356 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.31 |
| ▸ | WNT1 | P04628 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1001007 | 0.85 | ABL1 (0.39) | ATRLRRK2ALOX5APKDM4EALDH1A1 | |
| SCHEMBL7938626 | 0.78 | LMNA (0.39) | ATRPIM1LRRK2ALOX5APKDM4E | |
| SCHEMBL15520521 | 0.69 | FAAH (0.46) | ATRKDM4EALDH1A1LMNAMAPT | |
| SCHEMBL1001659 | 0.67 | FAAH (0.48) | ALDH1A1LMNA | |
| SCHEMBL1002632 | 0.64 | ABL1 (0.41) | ATRLRRK2ALOX5APKDM4EALDH1A1 | |
| SCHEMBL1001709 | 0.63 | FAAH (0.56) | ATR | |
| SCHEMBL12369754 | 0.60 | LRRK2 (0.52) | PIM1LRRK2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL27682172 | 0.59 | PIK3CD (0.52) | ATRLRRK2KDM4EALDH1A1LMNA | |
| SCHEMBL17870561 | 0.59 | PIK3CD (0.48) | LRRK2KDM4EALDH1A1LMNAMAPT | |
| SCHEMBL30968972 | 0.59 | CHRNA7 (0.40) | ATRPIM1LRRK2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010017079-A1 | OXAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | MERCK & CO., INC. (US) | 2010-02-11 | — | — | WO | disclosed |