Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 6/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7494824 | 1.00 | HRH3 (0.38) | HRH3RIPK1CYP2C19HIF1AKDM1A | |
| SCHEMBL7499703 | 0.87 | RIPK1 (0.38) | RIPK1 | |
| SCHEMBL7931953 | 0.87 | RIPK1 (0.38) | RIPK1 | |
| SCHEMBL7545959 | 0.79 | HRH3 (0.38) | HRH3RIPK1CYP2C19KDM1ARORC | |
| SCHEMBL4139712 | 0.76 | USP7 (0.40) | HRH3RIPK1KDM1ARORCSIGMAR1 | |
| SCHEMBL7972599 | 0.73 | CCR5 (0.44) | HRH3RIPK1KDM1ARORCSIGMAR1 | |
| SCHEMBL7499305 | 0.73 | CCR5 (0.44) | HRH3RIPK1KDM1ARORCSIGMAR1 | |
| SCHEMBL31611372 | 0.71 | TLR2 (0.38) | HRH3KDM1ARORCSIGMAR1SLC6A2 | |
| SCHEMBL2335935 | 0.71 | RORC (0.60) | RORC | |
| SCHEMBL2342856 | 0.71 | RORC (0.60) | RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248755-B1 | ANTIINFLAMMATORY AGENTS; ANTIALLERGENS; AUTOIMMUNE DISEASES | MERCK & CO., INC. | 2001-06-19 | — | — | US | disclosed |