Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.31 |
| ▸ | PNMT | P11086 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.34 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA6 | P23280 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8677895 | 0.97 | PNMT (0.42) | PNMTNPC1RAB9APGRHTR2B | |
| Hydrochloric Acid SCHEMBL8469546 | 0.80 | PNMT (0.41) | PNMTNPC1RAB9APGRHTR2B | |
| Hydrochloric Acid SCHEMBL3679753 | 0.79 | PNMT (0.36) | PNMTNPC1RAB9AHTR2BMAP3K9 | |
| SCHEMBL7055192 | 0.78 | PNMT (0.40) | PNMTNPC1RAB9APGRHTR2B | |
| Hydrochloric Acid SCHEMBL2763537 | 0.76 | PNMT (0.36) | PNMTNPC1RAB9AHTR2BMAP3K9 | |
| SCHEMBL524602 | 0.74 | PNMT (0.63) | PNMTNPC1RAB9APGRHTR2B | |
| SCHEMBL30103334 | 0.74 | PNMT (0.63) | PNMTNPC1RAB9APGRHTR2B | |
| Chloromethane SCHEMBL3685925 | 0.73 | PNMT (0.36) | PNMTNPC1RAB9AHTR2BHTR7 | |
| Chloromethane SCHEMBL3685930 | 0.72 | PNMT (0.35) | PNMTNPC1RAB9AHTR2BHTR7 | |
| Chloromethane SCHEMBL3679757 | 0.72 | PNMT (0.35) | PNMTNPC1RAB9AHTR2BHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666267-B1 | Organometallic fluorenyl compounds, preparation, and use | PHILLIPS PETROLEUM CO (US) | 2001-04-18 | — | — | EP | disclosed |