Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.31 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7933161 | 0.74 | NISCH (0.35) | NISCHACHERAB9A | |
| Hydrochloric Acid SCHEMBL7744064 | 0.71 | NISCH (0.35) | NISCHACHERAB9A | |
| Hydrochloric Acid SCHEMBL7936762 | 0.71 | — | — | |
| Hydrochloric Acid SCHEMBL7939082 | 0.67 | NISCH (0.33) | NISCHACHERAB9A | |
| Hydrochloric Acid SCHEMBL7935291 | 0.65 | NISCH (0.33) | NISCHFYNCLK4DYRK1B | |
| SCHEMBL301247 | 0.61 | ACHE (0.69) | NISCHACHERAB9A | |
| SCHEMBL31471473 | 0.61 | ACHE (0.69) | NISCHACHERAB9A | |
| SCHEMBL29373699 | 0.61 | ACHE (0.69) | NISCHACHERAB9A | |
| Hydrochloric Acid SCHEMBL7939104 | 0.61 | — | — | |
| SCHEMBL18797759 | 0.59 | ACHE (0.65) | NISCHACHERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6184402-B1 | RESOLUTION OF A STEREOISOMERIC MIXTURE OF SPECIFIC METALLOCENE COMPLEXES BRIDGED WITH A TRANSITION METAL HAVING AN OXYGEN BOND ATTACHED, I.E., A MU-OXO COMPLEX; HYDROLYSIS IN THE PRESENCE OF A BASE; SEPARATION OF MESO FORM FROM MIXES | CHISSO CORPORATION (JP) | 2001-02-06 | — | — | US | disclosed |