Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 3/20 | 0.37 |
| ▸ | PPARA | Q07869 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | ALOX15B | O15296 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11884620 | 0.90 | PDE5A (0.39) | CYP19A1PDE5APPARGPPARAHTT | |
| SCHEMBL7944691 | 0.79 | RAB9A (0.44) | PDE5AHTTALDH1A1RAB9ANPC1 | |
| SCHEMBL7939857 | 0.75 | ALDH1A1 (0.47) | HTTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL3529516 | 0.73 | ALDH1A1 (0.33) | PPARGPPARAPPARDALDH1A1ALOX15B | |
| SCHEMBL3534187 | 0.73 | ALDH1A1 (0.33) | PPARGPPARAPPARDALDH1A1ALOX15B | |
| SCHEMBL8049534 | 0.72 | MEN1 (0.58) | GAAMEN1KMT2APOLBMAPK1 | |
| SCHEMBL7933353 | 0.72 | DRD4 (0.50) | ALDH1A1PKMMAPTSMN1; SMN2MEN1 | |
| SCHEMBL3529333 | 0.71 | PPARG (0.31) | PPARGPPARAPPARDALDH1A1ALOX15B | |
| SCHEMBL3533966 | 0.71 | MEN1 (0.33) | PPARGPPARAPPARDALDH1A1ALOX15B | |
| SCHEMBL3527047 | 0.71 | CYP2C19 (0.34) | ALDH1A1ALOX15BRAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242448-B1 | Trisubstituted-oxazole derivatives as serotonin ligands | AMERICAN HOME PRODUCTS CORPORATION | 2001-06-05 | — | — | US | disclosed |
| EP-1053235-A1 | OXAZOLE DERIVATIVES AS SEROTONIN-1A RECEPTOR AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-11-22 | — | — | EP | disclosed |
| US-6057340-A | Oxazole derivatives as serotonin-1A receptor agonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-05-02 | — | — | US | disclosed |
| WO-1999038864-A1 | OXAZOLE DERIVATIVES AS SEROTONIN-1A RECEPTOR AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-08-05 | — | — | WO | disclosed |