Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.56 |
| ▸ | DRD2 | P14416 | 4/20 | 0.56 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7933353 | 0.82 | DRD4 (0.50) | HTR1ADRD2DRD4HTR7DRD3 | |
| SCHEMBL7939813 | 0.81 | HTR1A (0.58) | HTR1ADRD2DRD4HTR2AHTR7 | |
| SCHEMBL7939857 | 0.80 | ALDH1A1 (0.47) | HTR1ADRD2DRD4HTR7DRD3 | |
| SCHEMBL7939817 | 0.76 | MAPK1 (0.56) | DRD2DRD4HTR7DRD3 | |
| SCHEMBL13533015 | 0.76 | HTR1A (0.81) | HTR1ADRD2 | |
| SCHEMBL11884620 | 0.73 | PDE5A (0.39) | — | |
| SCHEMBL7940912 | 0.73 | MAPT (0.47) | HTR1ADRD2DRD4HTR2AHTR7 | |
| SCHEMBL13533020 | 0.72 | HTR1A (1.00) | HTR1ADRD2DRD4HTR2AHTR7 | |
| SCHEMBL8049534 | 0.72 | MEN1 (0.58) | DRD2DRD4 | |
| SCHEMBL7830509 | 0.71 | HTR1A (0.48) | HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242448-B1 | Trisubstituted-oxazole derivatives as serotonin ligands | AMERICAN HOME PRODUCTS CORPORATION | 2001-06-05 | — | — | US | claimed |
| US-6242448-B1 | Trisubstituted-oxazole derivatives as serotonin ligands | AMERICAN HOME PRODUCTS CORPORATION | 2001-06-05 | — | — | US | disclosed |