Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 14/20 | 0.35 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10502149 | 0.82 | HTT (0.40) | HTTNCOA1SMN1; SMN2NCOA3CRHR1 | |
| SCHEMBL7930932 | 0.79 | SLC29A1 (0.47) | HTTSMN1; SMN2SLC29A1KDM4EKMT2A | |
| SCHEMBL10502629 | 0.78 | CYP1A2 (0.39) | HTTNCOA1SMN1; SMN2NCOA3CRHR1 | |
| SCHEMBL7939933 | 0.76 | DNM1 (0.39) | CRHR1MAPTKMT2A | |
| SCHEMBL10803771 | 0.75 | MAPT (0.40) | SMN1; SMN2CRHR1SLC29A1MAPTNPSR1 | |
| SCHEMBL523376 | 0.75 | MAPT (0.42) | SMN1; SMN2CRHR1SLC29A1MAPTNPSR1 | |
| SCHEMBL10502321 | 0.71 | PDE1B (0.42) | HTTNCOA1SMN1; SMN2NCOA3CRHR1 | |
| SCHEMBL11469164 | 0.69 | CRHR1 (0.49) | SMN1; SMN2CRHR1SLC29A1MAPT | |
| SCHEMBL18826085 | 0.68 | MAT2A (0.35) | — | |
| SCHEMBL9487776 | 0.68 | MAPT (0.38) | SMN1; SMN2CRHR1SLC29A1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6232312-B1 | ADMINISTERING A COMBINATION OF INDENE AND PYRIMIDO(5,4-D)PYRIMIDINE DERIVATIVES TO TREAT PREPANCREATIC CANCER | CELL PATHWAYS, INC. | 2001-05-15 | — | — | US | disclosed |