Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6912932 | 0.78 | NPC1 (0.32) | NPC1HPGDMAPK1HTTRAB9A | |
| SCHEMBL6053728 | 0.78 | NPC1 (0.32) | NPC1HPGDMAPK1HTTRAB9A | |
| Hydrochloric Acid SCHEMBL28064770 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL966077 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL27631015 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL6811751 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL27518446 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL27487351 | 0.77 | — | — | |
| SCHEMBL6913287 | 0.76 | ALOX5 (0.32) | NPC1HPGDMAPK1HTTRAB9A | |
| Hydrochloric Acid SCHEMBL538950 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258904-B1 | Unbridged monocyclopentadienyl metal complex catalyst and a process for polyolefin production | UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION | 2001-07-10 | — | — | US | disclosed |
| US-6159889-A | Unbridged monocyclopentadienyl metal complex catalyst and a process for polyolefin production | UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) | 2000-12-12 | — | — | US | disclosed |
| US-6127302-A | Unbridged monocyclopentadienyl metal complex catalyst and a process for polyolefin production | UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) | 2000-10-03 | — | — | US | disclosed |
| EP-0989139-A1 | Unbridged monocyclopentadienyl metal complex catalyst for olefin polymerization by reacting with particulate solids with functional groups | UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) | 2000-03-29 | — | — | EP | disclosed |
| US-5962362-A | COORDINATION CATALYST | UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) | 1999-10-05 | — | — | US | disclosed |
| CN-1224025-A | Unbridged monocyclopentadienyl metal complex catalyst and process for polyolefin production | UNION CARBIDE CHEM PLASTIC (US) | 1999-07-28 | — | — | CN | disclosed |
| EP-0922711-A1 | Unbridged monocyclopentadienyl metal complex catalyst and a process for polyolefin production | UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) | 1999-06-16 | — | — | EP | disclosed |