Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 11/20 | 0.46 |
| ▸ | PDE4A | P27815 | 2/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | GCGR | P47871 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7404281 | 0.90 | MAPT (0.46) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL28131881 | 0.87 | PDE5A (0.52) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7939339 | 0.81 | ALDH1A1 (0.51) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10756097 | 0.81 | LTA4H (0.43) | MAPTALDH1A1LMNAHTTATM | |
| SCHEMBL28928070 | 0.78 | CYP1A2 (0.62) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL17292882 | 0.78 | CYP1A2 (0.62) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29365709 | 0.78 | CYP1A2 (0.62) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10646200 | 0.78 | HSP90AA1 (0.59) | ALDH1A1LMNATDP1CYP1A2CYP2C19 | |
| SCHEMBL8387581 | 0.77 | IDO1 (0.43) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10438816 | 0.77 | HTR7 (0.53) | PDE5APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6239136-B1 | REGULATING APOPTOSIS IN HUMAN CELLS HAVING AUTOIMMUNE DISEASE | CELL PATHWAYS, INC. | 2001-05-29 | — | — | US | disclosed |
| US-5874440-A | ADMINISTERING TO THE PATIENT HAVING PRECANCEROUS LESIONS TO INHIBIT GROWTH OF NEOPLASTIC CELLS | CELL PATHWAYS, INC. (US) | 1999-02-23 | — | — | US | disclosed |
| US-5118686-A | Administering bronchodilator agents for respiratory disorders | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-06-02 | — | — | US | disclosed |
| EP-0395328-A2 | Penylpyrimidone derivates and their use as therapeutic agents | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-10-31 | — | — | EP | disclosed |