Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | TYMS | P04818 | 1/20 | 0.39 |
| ▸ | SLC29A1 | Q99808 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7813634 | 0.99 | MEN1 (0.45) | MEN1LMNAKMT2AL3MBTL1ADORA2A | |
| SCHEMBL7816003 | 0.83 | HPGD (0.49) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7806218 | 0.82 | GAA (0.48) | MEN1KMT2AL3MBTL1ADORA2APDE5A | |
| SCHEMBL6548067 | 0.76 | L3MBTL1 (0.47) | MEN1LMNAKMT2AL3MBTL1ADORA2A | |
| Hydrochloric Acid SCHEMBL7813292 | 0.74 | DHFR (0.56) | MEN1LMNAKMT2AL3MBTL1ADORA2A | |
| SCHEMBL7812587 | 0.73 | SMN1; SMN2 (0.46) | MEN1KMT2AL3MBTL1SMN1; SMN2 | |
| SCHEMBL29601391 | 0.72 | MEN1 (0.46) | MEN1LMNAKMT2AADORA2AADORA1 | |
| SCHEMBL8177043 | 0.68 | ADORA2B (0.46) | LMNAPDE4AMAPT | |
| SCHEMBL28814905 | 0.68 | GAA (0.59) | MEN1LMNAKMT2AL3MBTL1SMN1; SMN2 | |
| SCHEMBL28017562 | 0.68 | MEN1 (0.55) | MEN1LMNAKMT2AL3MBTL1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6245910-B1 | Process for producing purine derivatives | AJINOMOTO CO., INC. (JP) | 2001-06-12 | — | — | US | disclosed |