SCHEMBL7941433

SCHEMBL7941433

O=C(O)[C@@H]1CN(C(=O)N(c2ccccc2)c2ccccc2)CCN1C(=O)N(c1ccccc1)c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR2 P50052 1/20 1.00
TACR1 P25103 2/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3516084 1.00 AGTR2 (1.00) AGTR2TACR1
SCHEMBL7389164 0.89 AGTR2 (0.79) AGTR2TACR1
SCHEMBL7384730 0.89 AGTR2 (0.79) AGTR2TACR1
SCHEMBL7384728 0.89 AGTR2 (0.79) AGTR2TACR1
SCHEMBL7389160 0.89 AGTR2 (0.79) AGTR2TACR1
SCHEMBL3515166 0.84 AGTR2 (0.72) AGTR2TACR1
SCHEMBL21311846 0.83 AGTR2 (0.70) AGTR2TACR1
SCHEMBL21311950 0.83 AGTR2 (0.70) AGTR2TACR1
SCHEMBL3518039 0.83 TACR1 (0.92) TACR1
SCHEMBL3514906 0.83 TACR1 (1.00) TACR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115843246-A Methods and compositions for treating hemangiomas 吉利斯麦金德研究院 2023-03-24 CN disclosed
US-20230090708-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF HEMANGIOMA MASSEY VENTURES LIMITED (NZ) 2023-03-23 US disclosed
EP-4096648-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF HEMANGIOMA Gillies Mcindoe Research Institute (NZ) 2022-12-07 EP disclosed
US-20210395231-A1 RECEPTOR INHIBITORS, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME AND USE THEREOF BEIJING TIDE PHARMACEUTICAL CO., LTD. (CN) 2021-12-23 US disclosed
EP-3760620-A1 RECEPTOR ANTAGONIST, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND USAGE THEREOF Beijing Tide Pharmaceutical Co., Ltd. (CN) 2021-01-06 EP disclosed
WO-2019161781-A1 RECEPTOR ANTAGONIST, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND USAGE THEREOF 北京泰德制药股份有限公司 2019-08-29 WO disclosed
EP-1830869-B1 METHOD OF TREATMENT OR PROPHYLAXIS SPINIFEX PHARM PTY LTD (AU) 2013-05-22 EP disclosed
US-6218414-B1 ADMINISTERING AN EFFECTIVE AMOUNT OF AN ANGIOTENSIN II ANTAGONIST AND A BENZOFURAN DERIVATIVE WITH ANTIARRHYTHMIC ACTIVITY FOR THERAPY OF CARDIOVASCULAR COMPLAINTS SANOFI (FR) 2001-04-17 US disclosed
US-5292726-A N,N-diacylpiperazines MERCK & CO., INC. (US) 1994-03-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210395231-A1 RECEPTOR INHIBITORS, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME AND USE THEREOF TACR1, TACR2, GPBAR1 AGTR2 13/4885TACR1 1/4885
US-20230090708-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF HEMANGIOMA AGTR2, AGTR1, AGT AGTR2 1/4885TACR1 52/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.