Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12517412 | 0.72 | LGMN (0.45) | HTTMEN1KMT2AALDH1A1POLB | |
| SCHEMBL3236220 | 0.72 | HTT (0.52) | HTTMEN1KMT2AALDH1A1POLB | |
| SCHEMBL7941017 | 0.71 | MAPK1 (0.47) | MEN1KMT2AALDH1A1POLBMAPK1 | |
| SCHEMBL1573415 | 0.71 | ALDH1A1 (0.64) | MEN1KMT2AALDH1A1POLBKDM4E | |
| SCHEMBL17542826 | 0.71 | LGMN (0.59) | HTTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL3436573 | 0.70 | MEN1 (0.61) | HTTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL3221137 | 0.69 | LGMN (0.61) | HTTMEN1KMT2AALDH1A1POLB | |
| SCHEMBL17305299 | 0.68 | LGMN (0.56) | HTTMEN1KMT2AALDH1A1POLB | |
| SCHEMBL3554337 | 0.68 | LGMN (0.65) | HTTMEN1KMT2AALDH1A1POLB | |
| SCHEMBL3225808 | 0.68 | POLB (0.59) | HTTMEN1KMT2AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015652-A2 | THIAZOLE COMPOUNDS AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |