Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CETP | P11597 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | UBE2N | P61088 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL27908345 | 0.93 | LMNA (0.46) | TDP1LMNACYP2D6SPHK1MAPT | |
| Propylene Glycol SCHEMBL27780105 | 0.91 | LMNA (0.50) | TDP1LMNACYP2D6SPHK1MAPT | |
| SCHEMBL16268114 | 0.86 | ALDH1A1 (0.43) | ALDH1A1LMNATSHRCYP2D6SPHK1 | |
| Propylene Glycol SCHEMBL8336557 | 0.86 | TDP1 (0.50) | TDP1ALDH1A1LMNATSHRCYP2D6 | |
| Ethylene Glycol SCHEMBL25302907 | 0.86 | ALDH1A1 (0.41) | ALDH1A1LMNATSHRFAAHHSD17B10 | |
| SCHEMBL635647 | 0.85 | DNM1 (0.41) | TDP1ALDH1A1LMNATSHRCYP3A4 | |
| SCHEMBL27495869 | 0.82 | ALDH1A1 (0.43) | ALDH1A1LMNATSHRCYP2D6SPHK1 | |
| SCHEMBL7943963 | 0.82 | TDP1 (0.47) | TDP1ALDH1A1MAPTUSP2HSD17B10 | |
| SCHEMBL8224489 | 0.81 | SPHK1 (0.37) | ALDH1A1SPHK1MAPTFAAHCNR1 | |
| Glycerin SCHEMBL9117304 | 0.81 | USP2 (0.48) | LMNACYP2D6SPHK1MAPTGMNN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1073685-A1 | WATER COMPATIBLE ENERGY CURABLE COMPOSITIONS CONTAINING MALEIMIDE DERIVATIVES | SUN CHEMICAL CORPORATION (US) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999048928-A1 | WATER COMPATIBLE ENERGY CURABLE COMPOSITIONS CONTAINING MALEIMIDE DERIVATIVES | SUN CHEMICAL CORPORATION (US) | 1999-09-30 | — | — | WO | disclosed |