Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 16/20 | 0.42 |
| ▸ | MMP13 | P45452 | 12/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 8/20 | 0.39 |
| ▸ | MMP8 | P22894 | 4/20 | 0.38 |
| ▸ | MMP1 | P03956 | 3/20 | 0.38 |
| ▸ | MMP14 | P50281 | 3/20 | 0.38 |
| ▸ | MMP3 | P08254 | 2/20 | 0.38 |
| ▸ | MMP16 | P51512 | 2/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6930517 | 0.76 | MMP9 (0.42) | MMP2MMP13HDAC1MMP9MMP8 | |
| SCHEMBL17118279 | 0.74 | MMP2 (0.41) | MMP2MMP13HDAC1ADAM17 | |
| SCHEMBL1770344 | 0.73 | MMP13 (0.58) | MMP2MMP13MMP9MMP8MMP1 | |
| SCHEMBL1770435 | 0.73 | MMP13 (0.58) | MMP2MMP13MMP9MMP8MMP1 | |
| SCHEMBL7946037 | 0.69 | MMP2 (0.64) | MMP2MMP13MMP9MMP8MMP3 | |
| SCHEMBL7948088 | 0.68 | MMP2 (0.68) | MMP2MMP13MMP9MMP8MMP1 | |
| SCHEMBL1771410 | 0.68 | MMP2 (0.68) | MMP2MMP13MMP9MMP8MMP1 | |
| SCHEMBL7948549 | 0.66 | MMP2 (0.71) | MMP2MMP13MMP9MMP8MMP1 | |
| SCHEMBL1770572 | 0.66 | MMP2 (0.82) | MMP2MMP13MMP9MMP8MMP1 | |
| SCHEMBL1770621 | 0.66 | MMP2 (0.71) | MMP2MMP13MMP9MMP8MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318361-B1 | SELECTIVE HYDROXAMIC ACID BASED MMP-12 AND MMP-13 INHIBITORS | NOVARTIS AG (CH) | 2015-09-23 | — | — | EP | disclosed |
| WO-2010007027-A1 | SELECTIVE HYDROXAMIC ACID BASED MMP-12 AND MMP-13 INHIBITORS | NOVARTIS AG (CH) | 2010-01-21 | — | — | WO | disclosed |