Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT6 | P42226 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.38 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | CCKBR | P32239 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7933189 | 0.90 | STAT6 (0.42) | STAT6KDM5ACYP51A1CCKBR | |
| SCHEMBL1930903 | 0.88 | AKR1C3 (0.39) | STAT6AKR1C3KDM5ACYP51A1L3MBTL3 | |
| SCHEMBL7942685 | 0.88 | STAT6 (0.47) | STAT6AKR1C3KDM5ACYP51A1HRH4 | |
| SCHEMBL14980527 | 0.86 | CYP51A1 (0.41) | STAT6AKR1C3KDM5ACYP51A1CCKBR | |
| SCHEMBL14980460 | 0.86 | STAT6 (0.41) | STAT6AKR1C3KDM5ACYP51A1CYP2C9 | |
| SCHEMBL14980442 | 0.85 | STAT6 (0.48) | STAT6AKR1C3CYP51A1HRH4CCKBR | |
| SCHEMBL7934440 | 0.85 | STAT6 (0.48) | STAT6AKR1C3CYP51A1HRH4CCKBR | |
| SCHEMBL14980528 | 0.85 | STAT6 (0.40) | STAT6AKR1C3KDM5ACYP51A1HRH4 | |
| SCHEMBL7934126 | 0.85 | STAT6 (0.48) | STAT6AKR1C3CYP51A1HRH4CCKBR | |
| SCHEMBL7945427 | 0.84 | STAT6 (0.45) | STAT6AKR1C3KDM5ACYP51A1HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010011914-A1 | TRPV4 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-01-28 | — | — | WO | disclosed |