SCHEMBL5480595

SCHEMBL5480595

CCOC(=O)/C=C1\CCOc2ccccc21

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTDSP1 Q9GZU7 4/20 0.43
TDP1 Q9NUW8 1/20 0.43
MAPT P10636 3/20 0.40
LMNA P02545 1/20 0.40
MDM2 Q00987 1/20 0.40
POLB P06746 1/20 0.39
ALDH1A1 P00352 4/20 0.38
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
ESR2 Q92731 1/20 0.38
NOTUM Q6P988 1/20 0.38
KDM4E B2RXH2 3/20 0.37
GAA P10253 1/20 0.37
HPGD P15428 1/20 0.37
RXFP1 Q9HBX9 1/20 0.37
GLA P06280 3/20 0.37
TP53 P04637 1/20 0.36
MAPK1 P28482 1/20 0.36
CASP1 P29466 1/20 0.36
HSD17B10 Q99714 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29961371 1.00 CTDSP1 (0.43) CTDSP1TDP1MAPTLMNAMDM2
SCHEMBL10463565 1.00 CTDSP1 (0.43) CTDSP1TDP1MAPTLMNAMDM2
SCHEMBL19968929 0.82 RXRA (0.47) MAPTKDM4E
SCHEMBL24867670 0.82 ALDH1A1 (0.39) CTDSP1TDP1MAPTLMNAPOLB
SCHEMBL10407756 0.82 CTDSP1 (0.40) CTDSP1TDP1MAPTLMNAPOLB
SCHEMBL31021614 0.82 ALDH1A1 (0.39) CTDSP1TDP1MAPTLMNAPOLB
SCHEMBL10407623 0.82 USP2 (0.41) CTDSP1TDP1MAPTLMNAPOLB
SCHEMBL10407805 0.81 TDP1 (0.42) CTDSP1TDP1MAPTLMNAPOLB
SCHEMBL1451062 0.80 TRPV1 (0.41) CTDSP1TDP1MAPTALDH1A1NPC1
SCHEMBL12214581 0.80 MAOB (0.59) ALDH1A1NPC1RAB9AHPGDNFKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11186564-B2 Dual NAV1.2/5HT2a inhibitors for treating CNS disorders SUNOVION PHARMACEUTICALS INC. (US) 2021-11-30 US disclosed
EP-3512843-B1 PLANT GROWTH REGULATOR COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2021-10-20 EP disclosed
US-11136292-B2 Plant growth regulator compounds SYNGENTA PARTICIPATIONS AG (CH) 2021-10-05 US disclosed
US-20190330148-A1 PLANT GROWTH REGULATOR COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2019-10-31 US disclosed
US-20190194163-A1 DUAL NAV1.2/5HT2a INHIBITORS FOR TREATING CNS DISORDERS SUNOVION PHARMACEUTICALS INC. (US) 2019-06-27 US disclosed
WO-2018050477-A1 PLANT GROWTH REGULATOR COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2018-03-22 WO disclosed
US-8383839-B2 Heterocyclidene acetamide derivative MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2013-02-26 US disclosed
US-8383839-B2 Heterocyclidene acetamide derivative MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2013-02-26 US disclosed
US-20110112071-A1 NOVEL HETEROCYCLIDENE ACETAMIDE DERIVATIVE MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2011-05-12 US disclosed
US-20110112071-A1 NOVEL HETEROCYCLIDENE ACETAMIDE DERIVATIVE MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2011-05-12 US disclosed
US-7910751-B2 Heterocyclidene acetamide derivative MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2011-03-22 US disclosed
US-7910751-B2 Heterocyclidene acetamide derivative MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2011-03-22 US disclosed
US-20070129358-A1 Sbstituted chroman derivatives, processes for their preparation and their use as antiinflammatory agents SCHERING AG (DE) 2007-06-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190194163-A1 DUAL NAV1.2/5HT2a INHIBITORS FOR TREATING CNS DISORDERS SCN2A, HTR2A, HTR2C CTDSP1 2680/4885TDP1 1066/4885MAPT 434/4885
US-20070129358-A1 Sbstituted chroman derivatives, processes for their preparation and their use as antiinflammatory agents TNF, CXCL8, MPO CTDSP1 1182/4885TDP1 3550/4885MAPT 4273/4885
US-11186564-B2 Dual NAV1.2/5HT2a inhibitors for treating CNS disorders SCN2A, HTR2A, HTR2C CTDSP1 2680/4885TDP1 1066/4885MAPT 434/4885
US-11136292-B2 Plant growth regulator compounds FGF1, MST1, CDC20 CTDSP1 2331/4885TDP1 4758/4885MAPT 3528/4885
US-20190330148-A1 PLANT GROWTH REGULATOR COMPOUNDS FGF1, MST1, CDC20 CTDSP1 2331/4885TDP1 4758/4885MAPT 3528/4885
US-20110112071-A1 NOVEL HETEROCYCLIDENE ACETAMIDE DERIVATIVE TRPV1, TRPV3, TRPA1 CTDSP1 4107/4885TDP1 4866/4885MAPT 4346/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.