Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR3 | P46089 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.32 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7772245 | 0.96 | TNKS2 (0.33) | GPR3HTR2ATNKS2PBRM1 | |
| Hydrochloric Acid SCHEMBL3770252 | 0.96 | TNKS2 (0.33) | GPR3HTR2ATNKS2PBRM1 | |
| Hydrochloric Acid SCHEMBL3119418 | 0.89 | GPR3 (0.40) | GPR3HTR2ATNKS2PBRM1 | |
| Hydrochloric Acid SCHEMBL6437753 | 0.78 | GPR3 (0.30) | GPR3HTR2A | |
| Hydrochloric Acid SCHEMBL30924226 | 0.76 | TNKS2 (0.35) | GPR3HTR2ATNKS2PBRM1 | |
| Hydrochloric Acid SCHEMBL7191825 | 0.76 | GPR3 (0.31) | GPR3HTR2A | |
| Hydrochloric Acid SCHEMBL339001 | 0.74 | KDM4E (0.33) | — | |
| Hydrochloric Acid SCHEMBL3759506 | 0.74 | KDM4E (0.33) | — | |
| Hydrochloric Acid SCHEMBL7754629 | 0.74 | BCHE (0.35) | — | |
| Hydrochloric Acid SCHEMBL7195306 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6297333-B1 | METALLOCENE TRANSITION METAL COMPOUND HAVING AN INDENYL GROUP AND A FLUORENYL GROUP AS LIGANDS, SPECIFIC SUBSTITUENT ON A SPECIFIC POSITION OF THE INDENYL GROUP GIVES HIGH MOLECULAR WEIGHT AND HIGH ACTIVITY | MITSUI CHEMICALS INC (JP) | 2001-10-02 | — | — | US | disclosed |
| US-6004897-A | TRANSITION METAL INDENE-FLUORINE COMPLEX COORDINATION CATALYST WITH ORGANOALUMINUM AND ALUMOXANE COMPOUNDS | MITSUI CHEMICALS, INC. (JP) | 1999-12-21 | — | — | US | disclosed |
| EP-0754698-A2 | An olefin polymerization catalyst and a process for preparing olefin polymer | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1997-01-22 | — | — | EP | disclosed |