Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 6/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.40 |
| ▸ | CLK2 | P49760 | 4/20 | 0.40 |
| ▸ | MAP4K2 | Q12851 | 4/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.40 |
| ▸ | AURKA | O14965 | 3/20 | 0.40 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.40 |
| ▸ | FLT1 | P17948 | 3/20 | 0.40 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.40 |
| ▸ | IGF1R | P08069 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.40 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.40 |
| ▸ | FER | P16591 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29930538 | 0.79 | DYRK1B (0.60) | PIM1NTRK1DYRK1AMAP4K4CLK2 | |
| SCHEMBL5061384 | 0.78 | DYRK1A (0.57) | PIM1DYRK1AMAP4K4CLK2MAP4K2 | |
| SCHEMBL28553148 | 0.78 | DYRK1B (0.56) | PIM1NTRK1DYRK1AMAP4K4CLK2 | |
| SCHEMBL28559332 | 0.76 | DYRK1A (0.44) | PIM1DYRK1AMAP4K4CLK2MAP4K2 | |
| SCHEMBL8320389 | 0.75 | DYRK1A (0.66) | DYRK1AMAP4K4CLK2MAP4K2AURKB | |
| SCHEMBL29930770 | 0.75 | DYRK1B (0.58) | DYRK1AMAP4K4CLK2MAP4K2AURKB | |
| SCHEMBL28562998 | 0.75 | DYRK1B (0.61) | DYRK1ASYKDYRK1BKDM4EALDH1A1 | |
| SCHEMBL28553364 | 0.74 | DYRK1B (0.39) | PIM1NTRK1DYRK1AMAP4K4CLK2 | |
| SCHEMBL1592867 | 0.73 | DYRK1B (0.44) | PIM1NTRK1DYRK1AMAP4K4CLK2 | |
| SCHEMBL29930372 | 0.73 | DYRK1B (0.60) | DYRK1AMAP4K4CLK2MAP4K2AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015803-A1 | DIAZAINDOLE DERIVATIVES AND THEIR USE IN THE INHIBITION OF C-JUN N-TERMINAL KINASE | EISAI R & D MANAGEMENT CO. LTD (JP) | 2010-02-11 | — | — | WO | disclosed |