Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | HTR1D | P28221 | 3/20 | 0.43 |
| ▸ | HTR1B | P28222 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7943447 | 0.82 | MCL1 (0.48) | MAPTALDH1A1HTR1AHTR1DHTR1B | |
| SCHEMBL5005300 | 0.78 | CA12 (0.53) | RXFP1ALDH1A1KDM4ELMNAHSD17B10 | |
| SCHEMBL27378256 | 0.77 | ALOX5 (0.49) | RXFP1MAPTALDH1A1KDM4ELMNA | |
| SCHEMBL22042092 | 0.77 | KDM4E (0.50) | RXFP1MAPTALDH1A1KDM4ELMNA | |
| SCHEMBL7873379 | 0.77 | ALDH1A1 (0.48) | RXFP1MAPTALDH1A1KDM4ELMNA | |
| SCHEMBL7881078 | 0.76 | KMT2A (0.50) | RXFP1MAPTALDH1A1KDM4ELMNA | |
| SCHEMBL7881168 | 0.76 | KDM4E (0.49) | RXFP1MAPTALDH1A1KDM4ELMNA | |
| SCHEMBL7873678 | 0.76 | KDM4E (0.46) | RXFP1ALDH1A1KDM4ELMNAHSD17B10 | |
| SCHEMBL11186759 | 0.76 | KDM4E (0.58) | RXFP1ALDH1A1KDM4ELMNAHSD17B10 | |
| SCHEMBL16218016 | 0.75 | KDM4E (0.50) | ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0773942-A1 | 4-INDOLE DERIVATIVES AS SEROTONIN AGONISTS AND ANTAGONISTS | PFIZER INC. (US) | 1997-05-21 | — | — | EP | claimed |
| WO-1996003400-A1 | 4-INDOLE DERIVATIVES AS SEROTONIN AGONISTS AND ANTAGONISTS | PFIZER INC. (US) | 1996-02-08 | — | — | WO | claimed |
| US-6255306-B1 | PSYCHOLOGICAL DISORDERS | MACOR JOHN E (US) | 2001-07-03 | — | — | US | disclosed |
| EP-0773942-A1 | 4-INDOLE DERIVATIVES AS SEROTONIN AGONISTS AND ANTAGONISTS | PFIZER INC. (US) | 1997-05-21 | — | — | EP | disclosed |
| WO-1996003400-A1 | 4-INDOLE DERIVATIVES AS SEROTONIN AGONISTS AND ANTAGONISTS | PFIZER INC. (US) | 1996-02-08 | — | — | WO | disclosed |