Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 5/20 | 0.47 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR6 | P50406 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 3/20 | 0.43 |
| ▸ | HTR1B | P28222 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7943441 | 0.82 | RXFP1 (0.44) | HTR1AMAPTESR1SMN1; SMN2HTR1D | |
| SCHEMBL3300361 | 0.81 | CCR2 (0.52) | HTR1ADRD2HTR2AHTR6KDM4E | |
| SCHEMBL7943338 | 0.76 | RXFP1 (0.59) | MAPTSMN1; SMN2HSD17B10KDM4EALDH1A1 | |
| SCHEMBL3295174 | 0.74 | F10 (0.49) | HTR1ADRD2HTR2AHTR6ESR1 | |
| SCHEMBL2276306 | 0.74 | SLC9A1 (0.64) | MCL1MAPTSMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL2326927 | 0.74 | MCL1 (0.57) | MCL1MAPTSMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL19343561 | 0.73 | MCL1 (0.56) | MCL1SMN1; SMN2HSD17B10KDM4EALDH1A1 | |
| SCHEMBL2324550 | 0.73 | MCL1 (0.56) | MCL1MAPTSMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL3306325 | 0.73 | MCL1 (0.56) | MCL1SMN1; SMN2HSD17B10KDM4EALDH1A1 | |
| SCHEMBL7812700 | 0.72 | HTR1A (0.57) | HTR1AMAPTHTR1DHTR1BHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6255306-B1 | PSYCHOLOGICAL DISORDERS | MACOR JOHN E (US) | 2001-07-03 | — | — | US | disclosed |
| EP-0773942-A1 | 4-INDOLE DERIVATIVES AS SEROTONIN AGONISTS AND ANTAGONISTS | PFIZER INC. (US) | 1997-05-21 | — | — | EP | disclosed |
| WO-1996003400-A1 | 4-INDOLE DERIVATIVES AS SEROTONIN AGONISTS AND ANTAGONISTS | PFIZER INC. (US) | 1996-02-08 | — | — | WO | disclosed |