SCHEMBL7943455

SCHEMBL7943455

C=COC(=O)c1cccc(C(C)(C)C)c1C(=O)OC=C

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.37
CA2 P00918 3/20 0.36
NR1H4 Q96RI1 1/20 0.34
TDP1 Q9NUW8 2/20 0.34
ATM Q13315 1/20 0.34
POLB P06746 1/20 0.33
MAPT P10636 1/20 0.33
ALDH1A1 P00352 2/20 0.33
TSHR P16473 2/20 0.33
HSD17B10 Q99714 1/20 0.33
GABRA1 P14867 1/20 0.33
GABRB2 P47870 1/20 0.33
ELANE P08246 1/20 0.32
KMT2A Q03164 1/20 0.31
ALOX12 P18054 1/20 0.31
CA12 O43570 2/20 0.31
CA1 P00915 2/20 0.31
CA7 P43166 2/20 0.31
CA9 Q16790 2/20 0.31
CA14 Q9ULX7 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7943458 0.91 GLRA3 (0.37) CYP3A4CA2NR1H4TDP1ATM
SCHEMBL246897 0.85 TDP1 (0.40) CYP3A4CA2TDP1ATMPOLB
SCHEMBL28079925 0.83 CYP3A4 (0.46) CYP3A4CA2TDP1MAPTALDH1A1
Vinyl Ether SCHEMBL23088820 0.81 TDP1 (0.37) CYP3A4CA2TDP1ATMPOLB
Acetic Acid SCHEMBL8519656 0.81 TDP1 (0.40) CYP3A4TDP1ATMPOLBMAPT
Fumaric Acid SCHEMBL7563314 0.79 SMN1; SMN2 (0.40) CYP3A4TDP1ATMPOLBMAPT
Fumaric Acid SCHEMBL7563318 0.79 SMN1; SMN2 (0.40) CYP3A4TDP1ATMPOLBMAPT
SCHEMBL363479 0.77 MAPT (0.41) CA2NR1H4TDP1ATMPOLB
SCHEMBL1899482 0.75 CYP3A4 (0.37) CYP3A4CA2TDP1ATMPOLB
SCHEMBL15175 0.73 CYP3A4 (0.55) CYP3A4TDP1ALDH1A1TSHRHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6300416-B1 USEFUL AS TIRE SIDEWALL OR TIRE TREAD; STRENGTH PROPERTIES AND BENDING FATIGUE RESISTANCE AND LOW FUEL CONSUMPTION MITSUI CHEMICALS, INC. (JP) 2001-10-09 US disclosed
CN-1216055-A RUBBER COMPOSITIONS FOR TIRES MITSUI CHEMICALS INC (JP) 1999-05-05 CN disclosed
EP-0889091-A1 RUBBER COMPOSITIONS FOR TIRES Mitsui Chemicals, Inc. (JP) 1999-01-07 EP disclosed