Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.35 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7563314 | 1.00 | SMN1; SMN2 (0.40) | SMN1; SMN2HTTTDP1ATMALDH1A1 | |
| SCHEMBL246897 | 0.92 | TDP1 (0.40) | TDP1ATMALDH1A1CYP3A4MAPT | |
| Acetic Acid SCHEMBL8519656 | 0.91 | TDP1 (0.40) | TDP1ATMALDH1A1CYP3A4TNFRSF1A | |
| Crotonic Acid SCHEMBL8640256 | 0.88 | TDP1 (0.33) | SMN1; SMN2HTTTDP1ATMALDH1A1 | |
| Vinyl Ether SCHEMBL23088820 | 0.88 | TDP1 (0.37) | TDP1ATMALDH1A1CYP3A4MAPT | |
| SCHEMBL7943458 | 0.79 | GLRA3 (0.37) | TDP1ATMALDH1A1CYP3A4MAPT | |
| SCHEMBL7943455 | 0.79 | CYP3A4 (0.37) | TDP1ATMALDH1A1CYP3A4MAPT | |
| SCHEMBL1899482 | 0.79 | CYP3A4 (0.37) | TDP1ATMALDH1A1CYP3A4MAPT | |
| Acetic Acid SCHEMBL12469814 | 0.79 | NR1H4 (0.31) | — | |
| SCHEMBL27473151 | 0.78 | KDM4E (0.42) | SMN1; SMN2TDP1ATMALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020190818-A1 | High frequency band pass filter | TDK CORPORATION (JP) | 2002-12-19 | — | — | US | disclosed |
| EP-0788118-B1 | Low dielectric polymer and film, substrate and electronic part using the same | TDK CORP (JP) | 2002-11-20 | — | — | EP | disclosed |
| US-5914283-A | FUMARIC ACID DIESTER MONOMER-CONTAINING POLYMER FILM; HEAT RESISTANCE, WEATHER RESISTANCE | TDK CORPORATION (JP) | 1999-06-22 | — | — | US | disclosed |
| EP-0788118-A1 | Low dielectric polymer and film, substrate and electronic part using the same | TDK Corporation (JP) | 1997-08-06 | — | — | EP | disclosed |