SCHEMBL7943458

SCHEMBL7943458

C=COC(=O)c1cccc(C(C)(C)C)c1C(=O)O

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GLRA3 O75311 1/20 0.37
GLRB P48167 1/20 0.37
ATM Q13315 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
CA2 P00918 3/20 0.34
CA12 O43570 2/20 0.34
CA1 P00915 2/20 0.34
CA7 P43166 2/20 0.34
CA9 Q16790 2/20 0.34
CA14 Q9ULX7 2/20 0.34
ALOX15 P16050 1/20 0.34
NR1H4 Q96RI1 1/20 0.33
RXRA P19793 1/20 0.33
RXRB P28702 1/20 0.33
RXRG P48443 1/20 0.33
CYP3A4 P08684 1/20 0.32
RBP4 P02753 1/20 0.32
POLB P06746 1/20 0.32
MAPT P10636 1/20 0.32
ELANE P08246 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7943455 0.91 CYP3A4 (0.37) ATMTDP1CA2CA12CA1
SCHEMBL246897 0.83 TDP1 (0.40) ATMTDP1CA2CA1CA9
Acetic Acid SCHEMBL8519656 0.82 TDP1 (0.40) ATMTDP1RXRARXRBRXRG
SCHEMBL28055266 0.81 TSHR (0.44) GLRA3GLRBATMCA2CA12
SCHEMBL1323710 0.81 CA2 (0.42) GLRA3GLRBATMTDP1CA2
Fumaric Acid SCHEMBL7563314 0.79 SMN1; SMN2 (0.40) ATMTDP1RXRARXRBRXRG
Fumaric Acid SCHEMBL7563318 0.79 SMN1; SMN2 (0.40) ATMTDP1RXRARXRBRXRG
SCHEMBL31229322 0.79 ALOX15 (0.47) GLRA3GLRBCA2CA12CA1
SCHEMBL1355526 0.79 ALOX15 (0.47) GLRA3GLRBCA2CA12CA1
Vinyl Ether SCHEMBL23088820 0.79 TDP1 (0.37) ATMTDP1CA2CA1CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6300416-B1 USEFUL AS TIRE SIDEWALL OR TIRE TREAD; STRENGTH PROPERTIES AND BENDING FATIGUE RESISTANCE AND LOW FUEL CONSUMPTION MITSUI CHEMICALS, INC. (JP) 2001-10-09 US disclosed
CN-1216055-A RUBBER COMPOSITIONS FOR TIRES MITSUI CHEMICALS INC (JP) 1999-05-05 CN disclosed
EP-0889091-A1 RUBBER COMPOSITIONS FOR TIRES Mitsui Chemicals, Inc. (JP) 1999-01-07 EP disclosed