Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.67 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.67 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.67 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.67 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.67 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8276782 | 1.00 | ADRA2A (0.67) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL11216012 | 0.98 | ADRA2A (0.65) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL11215563 | 0.83 | ADRA2A (0.49) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL11216197 | 0.82 | ADRA2A (0.47) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL13114395 | 0.81 | MAOA (0.47) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL3149524 | 0.76 | HTR2A (0.50) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL3157930 | 0.76 | ESR1 (0.47) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8276783 | 0.71 | FYN (0.56) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL3144482 | 0.71 | HTR1A (0.50) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL31549 | 0.71 | CYP3A4 (0.43) | HTR2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166004-B1 | New method for resolution of enantiomers of (3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)nitrile and their application to the synthesis of ivabradine | SERVIER LAB (FR) | 2010-10-06 | — | — | EP | disclosed |
| EP-2166004-A1 | New method for resolution of enantiomers of (3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)nitrile and their application to the synthesis of ivabradine | Les Laboratoires Servier (FR) | 2010-03-24 | — | — | EP | disclosed |
| WO-2010023383-A1 | NOVEL METHOD FOR RESOLVING THE ENANTIOMERS OF (3,4-DIMETHOXYBICYCLO[4.2.0]OCTA-13,5-TRIEN-7-YL)NITRILE AND USE IN THE SYNTHESIS OF IVABRADINE | LES LABORATOIRES SERVIER (FR) | 2010-03-04 | — | — | WO | disclosed |
| US-20100056778-A1 | Process for the resolution of enantiomers of (3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl) nitrile and application in the synthesis of ivabradine | LES LABORATOIRES SERVIER (FR) | 2010-03-04 | — | — | US | disclosed |
| WO-2005123659-A1 | METHOD OF SYNTHESISING (1S)-4,5-DIMETHOXY-1- (METHYLAMINOMETHYL)-BENZOCYCLOBUTANE AND THE ADDITION SALTS THEREOF, AND USE OF SAME FOR THE SYNTHESIS OF IVABRADINE AND THE PHARMACEUTICALLY-ACCEPTABLE ADDITION SALTS THEREOF | LES LABORATOIRES SERVIER (FR) | 2005-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056778-A1 | Process for the resolution of enantiomers of (3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl) nitrile and application in the synthesis of ivabradine | HCN4, NISCH, SCN5A | ADRA2A 193/4885ADRA2B 196/4885ADRA2C 60/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.