SCHEMBL7943756

SCHEMBL7943756

O=C(NC/C=C1\CCCc2ccccc21)C(F)(F)F

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 3/20 0.41
MTNR1B P49286 3/20 0.41
CYP19A1 P11511 5/20 0.39
CYP11B1 P15538 5/20 0.39
CYP11B2 P19099 5/20 0.39
MAPT P10636 3/20 0.39
MIF P14174 2/20 0.39
RXRA P19793 2/20 0.39
CYP2A6 P11509 1/20 0.37
MAOA P21397 1/20 0.37
MAOB P27338 1/20 0.37
NQO2 P16083 2/20 0.36
NPC1 O15118 2/20 0.36
RAB9A P51151 2/20 0.36
ALDH1A1 P00352 1/20 0.36
TP53 P04637 1/20 0.36
NFKB1 P19838 1/20 0.36
NFKB2 Q00653 1/20 0.36
RELA Q04206 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7943680 0.92 MTNR1A (0.43) MTNR1AMTNR1BCYP19A1CYP11B1CYP11B2
SCHEMBL7943684 0.92 MTNR1A (0.43) MTNR1AMTNR1BCYP19A1CYP11B1CYP11B2
SCHEMBL7943686 0.92 MTNR1A (0.43) MTNR1AMTNR1BCYP19A1CYP11B1CYP11B2
SCHEMBL7950257 0.82 RXRA (0.46) MTNR1AMTNR1BCYP19A1CYP11B1CYP11B2
SCHEMBL7952088 0.80 MTNR1A (0.62) MTNR1AMTNR1BMAPTNQO2NPC1
SCHEMBL7952086 0.80 MTNR1A (0.62) MTNR1AMTNR1BMAPTNQO2NPC1
SCHEMBL7952090 0.80 MTNR1A (0.62) MTNR1AMTNR1BMAPTNQO2NPC1
SCHEMBL7952097 0.77 MTNR1A (0.62) MTNR1AMTNR1BMAPTNQO2
SCHEMBL7952100 0.77 MTNR1A (0.62) MTNR1AMTNR1BMAPTNQO2
SCHEMBL7943667 0.77 CYP19A1 (0.44) MTNR1AMTNR1BCYP19A1CYP11B2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6235789-B1 GLANDULAR DISORDERS; SLEEP DISORDERS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-05-22 US disclosed
EP-0781271-A1 BENZOCYCLOALKENE COMPOUNDS, THEIR PRODUCTION AND USE Takeda Chemical Industries, Ltd. (JP) 1997-07-02 EP disclosed
WO-1996008466-A1 BENZOCYCLOALKENE COMPOUNDS, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-03-21 WO disclosed